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The corresponding \u03b1,\u03b1\u2010dichloro\u2010\u03b2\u2010hydroxyketones were obtained by treatment with trichloroisocyanuric acid in the absence of a catalyst. The latter reaction can be extended to other alkynols. These transformations can be used to prepare potentially useful halogenated building blocks. Preliminary mechanistic studies suggest that the reaction involves participation of the acetonitrile solvent in the formation of a 5\u2010halo\u20101,3\u2010oxazine intermediate.<\/jats:p>","DOI":"10.1002\/anie.201405348","type":"journal-article","created":{"date-parts":[[2014,8,21]],"date-time":"2014-08-21T19:57:06Z","timestamp":1408651026000},"page":"10747-10750","source":"Crossref","is-referenced-by-count":60,"title":["Regioselective Dihalohydration Reactions of Propargylic Alcohols: Gold\u2010Catalyzed and Noncatalyzed Reactions"],"prefix":"10.1002","volume":"53","author":[{"given":"Jarryl M.","family":"D'Oyley","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abil E.","family":"Aliev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom D.","family":"Sheppard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,8,21]]},"reference":[{"key":"e_1_2_2_1_2","unstructured":"\u00a0"},{"key":"e_1_2_2_2_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0031-1290503"},{"key":"e_1_2_2_3_2","doi-asserted-by":"publisher","DOI":"10.1021\/cs400922y"},{"key":"e_1_2_2_4_2","unstructured":"\u00a0"},{"key":"e_1_2_2_5_2","doi-asserted-by":"publisher","DOI":"10.1039\/C3CC48290A"},{"key":"e_1_2_2_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201202828"},{"key":"e_1_2_2_7_2","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1039\/C2OB27016A","volume":"11","author":"Ding Z.\u2010C.","year":"2013","journal-title":"Org. 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