{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T13:09:37Z","timestamp":1789736977483,"version":"4.0.1"},"reference-count":58,"publisher":"Wiley","issue":"47","license":[{"start":{"date-parts":[[2014,9,15]],"date-time":"2014-09-15T00:00:00Z","timestamp":1410739200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"University of Antwerp (BOF)"},{"name":"Research Foundation-Flanders (FWO)"},{"name":"Hercules Foundation"},{"name":"Netherlands Organization for Scientific Research (NWO)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Angew Chem Int Ed"],"published-print":{"date-parts":[[2014,11,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Multiple applications of isothioureas as fine chemicals (or their precursors) are known, but a general sustainable method for their synthesis was hitherto unavailable. We report a novel general approach towards\n                    <jats:italic>S<\/jats:italic>\n                    \u2010alkyl and\n                    <jats:italic>S<\/jats:italic>\n                    \u2010aryl isothioureas through a copper(I)\u2010catalyzed three\u2010component reaction between amines, isocyanides, and thiosulfonates. The formal synthesis of a superpotent sweetener further illustrates the applicability of our method.\n                  <\/jats:p>","DOI":"10.1002\/anie.201406717","type":"journal-article","created":{"date-parts":[[2014,9,15]],"date-time":"2014-09-15T16:57:17Z","timestamp":1410800237000},"page":"12849-12854","source":"Crossref","is-referenced-by-count":108,"title":["Sustainable Three\u2010Component Synthesis of Isothioureas from Isocyanides, Thiosulfonates, and Amines"],"prefix":"10.1002","volume":"53","author":[{"given":"Pieter","family":"Mampuys","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanping","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tj\u00f8stil","family":"Vlaar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eelco","family":"Ruijter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romano V. A.","family":"Orru","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bert U. 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