{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T04:19:44Z","timestamp":1791173984847,"version":"4.1.0"},"reference-count":38,"publisher":"Wiley","issue":"49","license":[{"start":{"date-parts":[[2014,10,6]],"date-time":"2014-10-06T00:00:00Z","timestamp":1412553600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Angew Chem Int Ed"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Following the biosynthesis of polyketide backbones by polyketide synthases (PKSs), post\u2010PKS modifications result in a significantly elevated level of structural complexity that renders the chemical synthesis of these natural products challenging. We report herein a total synthesis of the widely used polyketide insecticide spinosyn\u2005A by exploiting the prowess of both chemical and enzymatic methods. As more polyketide biosynthetic pathways are characterized, this chemoenzymatic approach is expected to become readily adaptable to streamlining the synthesis of other complex polyketides with more elaborate post\u2010PKS modifications.<\/jats:p>","DOI":"10.1002\/anie.201407806","type":"journal-article","created":{"date-parts":[[2014,10,6]],"date-time":"2014-10-06T21:40:49Z","timestamp":1412631649000},"page":"13553-13557","source":"Crossref","is-referenced-by-count":43,"title":["Chemoenzymatic Synthesis of Spinosyn\u2005A"],"prefix":"10.1002","volume":"53","author":[{"given":"Hak Joong","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sei\u2010hyun","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byung\u2010sun","family":"Jeon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Namho","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongson","family":"Pongdee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingquan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hung\u2010wen","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,10,6]]},"reference":[{"key":"e_1_2_2_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2010.02.001"},{"key":"e_1_2_2_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.479"},{"key":"e_1_2_2_3_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja4008722"},{"key":"e_1_2_2_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200806121"},{"key":"e_1_2_2_4_3","doi-asserted-by":"publisher","DOI":"10.1002\/ange.200806121"},{"key":"e_1_2_2_5_2","doi-asserted-by":"publisher","DOI":"10.1039\/b911956f"},{"key":"e_1_2_2_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/ja.2010.5"},{"key":"e_1_2_2_7_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja00064a011"},{"key":"e_1_2_2_8_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja974009l"},{"key":"e_1_2_2_9_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja974010k"},{"key":"e_1_2_2_10_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0401247101"},{"key":"e_1_2_2_11_2","doi-asserted-by":"publisher","DOI":"10.1021\/jo101124n"},{"key":"e_1_2_2_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201107386"},{"key":"e_1_2_2_12_3","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201107386"},{"key":"e_1_2_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-5521(01)00029-1"},{"key":"e_1_2_2_14_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja0649670"},{"key":"e_1_2_2_15_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja076580i"},{"key":"e_1_2_2_16_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja0771383"},{"key":"e_1_2_2_17_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M808441200"},{"key":"e_1_2_2_18_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja910223x"},{"key":"e_1_2_2_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature09981"},{"key":"e_1_2_2_20_2","doi-asserted-by":"publisher","DOI":"10.1246\/bcsj.78.537"},{"key":"e_1_2_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2011.12.017"},{"key":"e_1_2_2_22_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi201860q"},{"key":"e_1_2_2_23_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi5003629"},{"key":"e_1_2_2_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jim.7000180"},{"key":"e_1_2_2_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2005.08.017"},{"key":"e_1_2_2_26_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja963195c"},{"key":"e_1_2_2_27_2","doi-asserted-by":"publisher","DOI":"10.1246\/cl.1988.843"},{"key":"e_1_2_2_28_2","doi-asserted-by":"publisher","DOI":"10.1021\/jo001387r"},{"key":"e_1_2_2_29_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja00162a047"},{"key":"e_1_2_2_30_2","doi-asserted-by":"publisher","DOI":"10.1021\/jo00001a072"},{"key":"e_1_2_2_31_2","doi-asserted-by":"publisher","DOI":"10.1021\/ar960223n"},{"key":"e_1_2_2_32_2","unstructured":"See the Supporting Information."},{"key":"e_1_2_2_33_2","doi-asserted-by":"publisher","DOI":"10.1021\/ol0511833"},{"key":"e_1_2_2_34_2","doi-asserted-by":"publisher","DOI":"10.1021\/ol0400342"},{"key":"e_1_2_2_35_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja00283a046"},{"key":"e_1_2_2_36_2","doi-asserted-by":"publisher","DOI":"10.1246\/bcsj.52.1989"}],"container-title":["Angewandte Chemie International Edition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fanie.201407806","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anie.201407806","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T06:46:49Z","timestamp":1697525209000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/anie.201407806"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10,6]]},"references-count":38,"journal-issue":{"issue":"49","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["10.1002\/anie.201407806"],"URL":"https:\/\/doi.org\/10.1002\/anie.201407806","archive":["Portico"],"relation":{},"ISSN":["1433-7851","1521-3773"],"issn-type":[{"value":"1433-7851","type":"print"},{"value":"1521-3773","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,10,6]]}}}