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Multifunctional protein micelles bearing targeting and therapeutic proteins were now obtained by one\u2010pot transpeptidation using an evolved sortase\u2005A. Conjugation to the corona of a single\u2010chain antibody (scFv), which binds to the ligand\u2010induced binding site (LIBS) of activated GPIIb\/IIIa receptors, enabled the efficient detection of thrombi. The inhibition of thrombus formation was subsequently accomplished by incorporating the catalytically active domain of thrombomodulin (TM) onto the micelle corona for the local generation of activated protein\u2005C, which inhibits the formation of thrombin. 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