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We report an atomic\u2010resolution fibril structure of the A\u03b21\u201040 peptide with the Osaka mutation (E22\u0394), associated with early\u2010onset AD. The structure, which differs substantially from all previously proposed models, is based on a large number of unambiguous intra\u2010 and intermolecular solid\u2010state NMR distance restraints.<\/jats:p>","DOI":"10.1002\/anie.201408598","type":"journal-article","created":{"date-parts":[[2014,11,13]],"date-time":"2014-11-13T14:58:22Z","timestamp":1415890702000},"page":"331-335","source":"Crossref","is-referenced-by-count":286,"title":["Atomic\u2010Resolution Three\u2010Dimensional Structure of Amyloid \u03b2 Fibrils Bearing the Osaka Mutation"],"prefix":"10.1002","volume":"54","author":[{"given":"Anne K.","family":"Sch\u00fctz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toni","family":"Vagt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Huber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oxana Y.","family":"Ovchinnikova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo","family":"Cadalbert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Wall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"G\u00fcntert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anja","family":"B\u00f6ckmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rudi","family":"Glockshuber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beat H.","family":"Meier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,11,13]]},"reference":[{"key":"e_1_2_2_1_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1072994"},{"key":"e_1_2_2_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1566067"},{"key":"e_1_2_2_3_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1151839"},{"key":"e_1_2_2_4_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja104213j"},{"key":"e_1_2_2_5_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1219476110"},{"key":"e_1_2_2_6_2","doi-asserted-by":"publisher","DOI":"10.1021\/ar300282r"},{"key":"e_1_2_2_7_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.262663499"},{"key":"e_1_2_2_8_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0506723102"},{"key":"e_1_2_2_9_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja2035859"},{"key":"e_1_2_2_10_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0806270105"},{"key":"e_1_2_2_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb.1799"},{"key":"e_1_2_2_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201200965"},{"key":"e_1_2_2_12_3","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201200965"},{"key":"e_1_2_2_13_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi051952q"},{"key":"e_1_2_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.08.035"},{"key":"e_1_2_2_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201311106"},{"key":"e_1_2_2_15_3","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201311106"},{"key":"e_1_2_2_16_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1111305109"},{"key":"e_1_2_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.05.057"},{"key":"e_1_2_2_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms3575"},{"key":"e_1_2_2_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature06108"},{"key":"e_1_2_2_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21321"},{"key":"e_1_2_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2011.02.049"},{"key":"e_1_2_2_22_2","doi-asserted-by":"publisher","DOI":"10.3109\/13506129.2011.580399"},{"key":"e_1_2_2_23_2","unstructured":"M. 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