{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T14:25:39Z","timestamp":1773411939408,"version":"3.50.1"},"reference-count":44,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,12,21]],"date-time":"2014-12-21T00:00:00Z","timestamp":1419120000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Angew Chem Int Ed"],"published-print":{"date-parts":[[2015,1,19]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The kinetics of the interactions between amyloid\u2010\u03b2 (A\u03b2) and metal ions are crucial to understanding the physiological and pathological roles of A\u03b2 in the normal brain and in Alzheimer\u2019s disease. Using the quenching of a fluorescent probe by Cu<jats:sup>2+<\/jats:sup>, the mechanism of A\u03b2\/Cu<jats:sup>2+<\/jats:sup> interactions in physiologically relevant conditions has been elucidated. Cu<jats:sup>2+<\/jats:sup> binds to A\u03b2 at a near diffusion\u2010limited rate, initially forming component\u2005I. The switching between component\u2005I and II occurs on the second timescale, with a significant energy barrier. Component\u2005I is much more reactive towards Cu<jats:sup>2+<\/jats:sup> ligands and likely responsible for initial A\u03b2 dimer formation. Clioquinol (CQ) is shown to sequester Cu<jats:sup>2+<\/jats:sup> more effectively than other tested ligands. These findings have implications for the potential roles of A\u03b2 in regulating neurotransmission, and for the screening of small molecules targeting A\u03b2\u2013metal interactions.<\/jats:p>","DOI":"10.1002\/anie.201408810","type":"journal-article","created":{"date-parts":[[2014,12,21]],"date-time":"2014-12-21T23:49:52Z","timestamp":1419205792000},"page":"1227-1230","source":"Crossref","is-referenced-by-count":49,"title":["Introduction of a Fluorescent Probe to Amyloid\u2010\u03b2 to Reveal Kinetic Insights into Its Interactions with Copper(II)"],"prefix":"10.1002","volume":"54","author":[{"given":"Thomas","family":"Branch","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Girvan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mauricio","family":"Barahona","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liming","family":"Ying","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,12,21]]},"reference":[{"key":"e_1_2_2_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd3505"},{"key":"e_1_2_2_2_2","unstructured":"\u00a0"},{"key":"e_1_2_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(03)00067-5"},{"key":"e_1_2_2_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2011.01221.x"},{"key":"e_1_2_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2013.01.023"},{"key":"e_1_2_2_6_2","unstructured":"\u00a0"},{"key":"e_1_2_2_7_2","doi-asserted-by":"crossref","first-page":"49","DOI":"10.3233\/JAD-2012-129039","volume":"33","author":"Klein W. L.","year":"2013","journal-title":"J. Alzheimer\u2032s Dis."},{"key":"e_1_2_2_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3028"},{"key":"e_1_2_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nurt.2008.05.001"},{"key":"e_1_2_2_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2011.07402.x"},{"key":"e_1_2_2_11_2","unstructured":"\u00a0"},{"key":"e_1_2_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2005.10.028"},{"key":"e_1_2_2_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2433"},{"key":"e_1_2_2_14_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0033583510000120"},{"key":"e_1_2_2_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1784"},{"key":"e_1_2_2_16_2","unstructured":"\u00a0"},{"key":"e_1_2_2_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.1996.tb01189.x"},{"key":"e_1_2_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(02)02245-2"},{"key":"e_1_2_2_19_2","doi-asserted-by":"publisher","DOI":"10.1039\/B813398K"},{"key":"e_1_2_2_20_2","unstructured":"\u00a0"},{"key":"e_1_2_2_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200904567"},{"key":"e_1_2_2_21_3","doi-asserted-by":"publisher","DOI":"10.1002\/ange.200904567"},{"key":"e_1_2_2_22_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja903669a"},{"key":"e_1_2_2_23_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja808073b"},{"key":"e_1_2_2_24_2","doi-asserted-by":"publisher","DOI":"10.1021\/ic201739n"},{"key":"e_1_2_2_25_2","unstructured":"\u00a0"},{"key":"e_1_2_2_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200904512"},{"key":"e_1_2_2_26_3","doi-asserted-by":"publisher","DOI":"10.1002\/ange.200904512"},{"key":"e_1_2_2_27_2","doi-asserted-by":"publisher","DOI":"10.1021\/ar400293h"},{"key":"e_1_2_2_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2007.02.002"},{"key":"e_1_2_2_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2013.12.005"},{"key":"e_1_2_2_30_2","unstructured":"\u00a0"},{"key":"e_1_2_2_31_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201006335"},{"key":"e_1_2_2_31_3","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201006335"},{"key":"e_1_2_2_32_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja076282l"},{"key":"e_1_2_2_33_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200906670"},{"key":"e_1_2_2_33_3","doi-asserted-by":"publisher","DOI":"10.1002\/ange.200906670"},{"key":"e_1_2_2_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2012.03.034"},{"key":"e_1_2_2_35_2","doi-asserted-by":"publisher","DOI":"10.1021\/ac302629u"},{"key":"e_1_2_2_36_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201005838"},{"key":"e_1_2_2_36_3","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201005838"},{"key":"e_1_2_2_37_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1006091107"},{"key":"e_1_2_2_38_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1222478110"},{"key":"e_1_2_2_39_2","doi-asserted-by":"publisher","DOI":"10.1021\/ar500152x"}],"container-title":["Angewandte Chemie International Edition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fanie.201408810","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anie.201408810","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T10:24:45Z","timestamp":1697451885000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/anie.201408810"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12,21]]},"references-count":44,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,1,19]]}},"alternative-id":["10.1002\/anie.201408810"],"URL":"https:\/\/doi.org\/10.1002\/anie.201408810","archive":["Portico"],"relation":{},"ISSN":["1433-7851","1521-3773"],"issn-type":[{"value":"1433-7851","type":"print"},{"value":"1521-3773","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,12,21]]}}}