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This natural product has also been shown to have excellent bactericidal activity against multidrug\u2010resistant <jats:italic>Mycobacterium tuberculosis<\/jats:italic>. In spite of its attractive biological activity, no total synthesis has been reported to date. The enantioselective synthesis of the central 18\u2010membered macrolactone is reported herein. The key reactions include ring\u2010closing metathesis between a terminal olefin and a dienoate moiety for macrocyclization, a vinylogous Mukaiyama aldol reaction, and a Stille coupling reaction of sterically demanding substrates. The retrosynthesis involves three medium\u2010sized fragments, thus leading to a flexible yet convergent synthetic route.<\/jats:p>","DOI":"10.1002\/anie.201409464","type":"journal-article","created":{"date-parts":[[2014,11,28]],"date-time":"2014-11-28T14:24:11Z","timestamp":1417184651000},"page":"1933-1936","source":"Crossref","is-referenced-by-count":67,"title":["Total Synthesis of the Protected Aglycon of Fidaxomicin (Tiacumicin\u2005B, Lipiarmycin\u2005A3)"],"prefix":"10.1002","volume":"54","author":[{"given":"Hideki","family":"Miyatake\u2010Ondozabal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elias","family":"Kaufmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl","family":"Gademann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,11,27]]},"reference":[{"key":"e_1_2_2_1_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkn269"},{"key":"e_1_2_2_2_2","doi-asserted-by":"publisher","DOI":"10.1086\/505877"},{"key":"e_1_2_2_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2010.135"},{"key":"e_1_2_2_4_2","doi-asserted-by":"publisher","DOI":"10.1039\/C2NP20080E"},{"key":"e_1_2_2_4_3","first-page":"237","volume":"9","author":"Bedeschi A.","year":"2014","journal-title":"Nat. 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