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Herein, a universal donor\u2010cell\u2010assisted membrane biotinylation strategy was proposed for labeling MPs by skillfully utilizing the natural membrane phospholipid exchange of their donor cells. This innovative strategy conveniently led to specific, efficient, reproducible, and biocompatible quantum dot (QD) labeling of MPs, thereby reliably conferring valuable traceability on MPs. By further loading with small interference RNA, QD\u2010labeled MPs that had inherent cell\u2010targeting and biomolecule\u2010conveying ability were successfully employed for combined bioimaging and tumor\u2010targeted therapy. This study provides the first reliable and biofriendly strategy for transforming biogenic MPs into functionalized nanovectors.<\/jats:p>","DOI":"10.1002\/anie.201410223","type":"journal-article","created":{"date-parts":[[2014,11,20]],"date-time":"2014-11-20T23:09:56Z","timestamp":1416524996000},"page":"1036-1040","source":"Crossref","is-referenced-by-count":94,"title":["Transformation of Cell\u2010Derived Microparticles into Quantum\u2010Dot\u2010Labeled Nanovectors for Antitumor siRNA Delivery"],"prefix":"10.1002","volume":"54","author":[{"given":"Gang","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun\u2010Yi","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi\u2010Ling","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian\u2010Gang","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng\u2010Yuan","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dai\u2010Wen","family":"Pang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi\u2010Fang","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,11,20]]},"reference":[{"key":"e_1_2_2_1_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.110.226456"},{"key":"e_1_2_2_2_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201211138"},{"key":"e_1_2_2_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.113.300858"},{"key":"e_1_2_2_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms2282"},{"key":"e_1_2_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2014.02.003"},{"key":"e_1_2_2_6_2","doi-asserted-by":"publisher","DOI":"10.1021\/nn400269x"},{"key":"e_1_2_2_7_2","doi-asserted-by":"publisher","DOI":"10.1039\/c3nr01541f"},{"key":"e_1_2_2_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-61737-950-5_16"},{"key":"e_1_2_2_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.1248"},{"key":"e_1_2_2_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-011-0198-4"},{"key":"e_1_2_2_11_2","doi-asserted-by":"publisher","DOI":"10.1021\/nn2031353"},{"key":"e_1_2_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2013.11.069"},{"key":"e_1_2_2_13_2","doi-asserted-by":"publisher","DOI":"10.1021\/cb2001878"},{"key":"e_1_2_2_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.001720"},{"key":"e_1_2_2_15_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja2089553"},{"key":"e_1_2_2_16_2","doi-asserted-by":"publisher","DOI":"10.1021\/nn405744f"},{"key":"e_1_2_2_17_2","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2012.185363"},{"key":"e_1_2_2_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10456-010-9187-8"}],"container-title":["Angewandte Chemie International Edition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fanie.201410223","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anie.201410223","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T09:28:30Z","timestamp":1697448510000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/anie.201410223"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11,20]]},"references-count":18,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,1,12]]}},"alternative-id":["10.1002\/anie.201410223"],"URL":"https:\/\/doi.org\/10.1002\/anie.201410223","archive":["Portico"],"relation":{},"ISSN":["1433-7851","1521-3773"],"issn-type":[{"value":"1433-7851","type":"print"},{"value":"1521-3773","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,11,20]]}}}