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Gallic acid based gallotannins are among these polyphenols, but their antifibrillogenic activity has thus far been examined using \u201ctannic acid\u201d, a commercial mixture of gallotannins and other galloylated glucopyranoses. The first total syntheses of two true gallotannins, a hexagalloylglucopyranose and a decagalloylated compound whose structure is commonly used to depict \u201ctannic acid\u201d, are now described. These depsidic gallotannins and simpler galloylated glucose derivatives all inhibit amyloid \u03b2\u2010peptide (A\u03b2) aggregation in\u2005vitro, and monogalloylated \u03b1\u2010glucogallin and a natural \u03b2\u2010hexagalloylglucose are shown to be the strongest inhibitors.<\/jats:p>","DOI":"10.1002\/anie.201411606","type":"journal-article","created":{"date-parts":[[2015,5,27]],"date-time":"2015-05-27T13:04:26Z","timestamp":1432731866000},"page":"8217-8221","source":"Crossref","is-referenced-by-count":64,"title":["Gallotannins and Tannic Acid: First Chemical Syntheses and In Vitro Inhibitory Activity on Alzheimer\u2019s Amyloid \u03b2\u2010Peptide Aggregation"],"prefix":"10.1002","volume":"54","author":[{"given":"Tahiri","family":"Sylla","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Pouys\u00e9gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gr\u00e9gory","family":"Da\u2005Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis","family":"Deffieux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Pierre","family":"Monti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"Quideau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,5,26]]},"reference":[{"key":"e_1_2_2_1_2","unstructured":"World Alzheimer Report(Eds.: M. 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