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This method was applied to the concise synthesis of a potent matrix metalloproteinase (MMP) inhibitor.<\/jats:p>","DOI":"10.1002\/anie.201502324","type":"journal-article","created":{"date-parts":[[2015,5,8]],"date-time":"2015-05-08T19:48:17Z","timestamp":1431114497000},"page":"7410-7413","source":"Crossref","is-referenced-by-count":43,"title":["Direct Synthesis of 5\u2010Aryl Barbituric Acids by Rhodium(II)\u2010Catalyzed Reactions of Arenes with Diazo Compounds"],"prefix":"10.1002","volume":"54","author":[{"given":"Daniel","family":"Best","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David J.","family":"Burns","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hon Wai","family":"Lam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,5,8]]},"reference":[{"key":"e_1_2_2_1_2","unstructured":"\u00a0"},{"key":"e_1_2_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-2725(08)60921-6"},{"key":"e_1_2_2_3_2","first-page":"329","volume":"1","author":"L\u00f3pez\u2010Mu\u00f1oz F.","year":"2005","journal-title":"Neuropsychiatr. 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Except for [Rh2{(S)\u2010TFPTTL}4] these gave inferior results. See the Supporting Information for full details."},{"key":"e_1_2_2_81_2","unstructured":"For2\u2009b\u20132\u2009h we believe the minor regioisomer to be the 1 2\u2010disubstituted arene based on the isolation of7(Scheme\u20053)."},{"key":"e_1_2_2_82_2","doi-asserted-by":"publisher","DOI":"10.1021\/cr00002a004"},{"key":"e_1_2_2_83_2","unstructured":"Cyclic 2\u2010diazo\u20101 3\u2010diones gave complex mixtures (see Ref.\u2005[22\u2009b \u2009c]) whereas 3\u2010diazobenzopyran\u20102 4(3H)\u2010dione underwent successful arylation at room temperature but with poor regioselectivities compared with Ref.\u2005[22\u2009e]. The 2\u2010diazo derivative of Meldrum\u2019s acid appeared to react well but decomposition of the arylation products during chromatography prevented their clean isolation."},{"key":"e_1_2_2_84_2","unstructured":"The use ofN\u2010bromosuccinimide (NBS) and BzOOBz in CCl4or Br2and HBr in AcOH gave yields of 52\u2009% and 56\u2009% respectively for the same reaction; see Ref.\u2005[5\u2009a]."},{"key":"e_1_2_2_85_2","unstructured":"For reviews on C(sp3)\uf8ffH insertion reactions with rhodium(II) carbenoid complexes see:"},{"key":"e_1_2_2_86_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature06485"},{"key":"e_1_2_2_87_2","doi-asserted-by":"publisher","DOI":"10.1039\/c0cs00217h"}],"container-title":["Angewandte Chemie International Edition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fanie.201502324","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anie.201502324","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T13:02:56Z","timestamp":1697461376000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/anie.201502324"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5,8]]},"references-count":91,"journal-issue":{"issue":"25","published-print":{"date-parts":[[2015,6,15]]}},"alternative-id":["10.1002\/anie.201502324"],"URL":"https:\/\/doi.org\/10.1002\/anie.201502324","archive":["Portico"],"relation":{},"ISSN":["1433-7851","1521-3773"],"issn-type":[{"value":"1433-7851","type":"print"},{"value":"1521-3773","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,5,8]]}}}