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Herein we report a novel surface\u2010enhanced Raman scattering (SERS) nanosensor, 4\u2010acetamidobenzenesulfonyl azide\u2010functionalized gold nanoparticles (AuNPs\/4\u2010AA), for detecting the endogenous H<jats:sub>2<\/jats:sub>S in living cells. The detection is accomplished with SERS spectrum changes of AuNPs\/4\u2010AA resulting from the reaction of H<jats:sub>2<\/jats:sub>S with 4\u2010AA on AuNPs. The SERS nanosensor exhibits high selectivity toward H<jats:sub>2<\/jats:sub>S. Furthermore, AuNPs\/4\u2010AA responds to H<jats:sub>2<\/jats:sub>S within 1\u2005min with a 0.1\u2005\u03bc<jats:sc>M<\/jats:sc> level of sensitivity. In particular, our SERS method can be utilized to monitor the endogenous H<jats:sub>2<\/jats:sub>S generated in living glioma cells, demonstrating its great promise in studies of pathophysiological pathways involving H<jats:sub>2<\/jats:sub>S.<\/jats:p>","DOI":"10.1002\/anie.201505025","type":"journal-article","created":{"date-parts":[[2015,8,28]],"date-time":"2015-08-28T11:41:08Z","timestamp":1440762068000},"page":"12758-12761","source":"Crossref","is-referenced-by-count":156,"title":["Monitoring of Endogenous Hydrogen Sulfide in Living Cells Using Surface\u2010Enhanced Raman 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