{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T14:33:16Z","timestamp":1783607596443,"version":"3.55.0"},"reference-count":98,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,10,21]],"date-time":"2015-10-21T00:00:00Z","timestamp":1445385600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002241","name":"Japan Science and Technology Agency","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002241","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Angew Chem Int Ed"],"published-print":{"date-parts":[[2016,1,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Enantioselective trichloromethylation of Morita\u2013Baylis\u2013Hillman (MBH)\u2010type allylic fluorides with chloroform (HCCl<jats:sub>3<\/jats:sub>) under organocatalysis was achieved with high to excellent enantioselectivities. Silicon\u2010assisted C\u2212F bond activation by a Ruppert\u2013Prakash reagent and direct activation of HCCl<jats:sub>3<\/jats:sub> by a carbanion exchange process with trifluoromethyl (CF<jats:sub>3<\/jats:sub>) carbanion generated in\u2005situ from the Ruppert\u2010Prakash reagent realized the direct asymmetric trichloromethylation at a stereogenic allylic positon, without any help from transition metal catalysis, and under very mild conditions. Pre\u2010activation of HCCl<jats:sub>3<\/jats:sub> was not required. This method was extended to the direct enantioselective introduction of other C\u2212H compounds such as alkyne, arene, indene, and FBSM without any pre\u2010activation under a metal\u2010free system.<\/jats:p>","DOI":"10.1002\/anie.201508574","type":"journal-article","created":{"date-parts":[[2015,10,22]],"date-time":"2015-10-22T05:44:00Z","timestamp":1445492640000},"page":"359-363","source":"Crossref","is-referenced-by-count":66,"title":["Enantioselective Trichloromethylation of MBH\u2010Fluorides with Chloroform Based on Silicon\u2010assisted C\u2212F Activation and Carbanion Exchange Induced by a Ruppert\u2013Prakash Reagent"],"prefix":"10.1002","volume":"55","author":[{"given":"Takayuki","family":"Nishimine","sequence":"first","affiliation":[{"name":"Department of Frontier Materials Nagoya Institute of Technology, Gokiso  Showa-ku, Nagoya 466-8555 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiromi","family":"Taira","sequence":"additional","affiliation":[{"name":"Department of Frontier Materials Nagoya Institute of Technology, Gokiso  Showa-ku, Nagoya 466-8555 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Etsuko","family":"Tokunaga","sequence":"additional","affiliation":[{"name":"Department of Frontier Materials Nagoya Institute of Technology, Gokiso  Showa-ku, Nagoya 466-8555 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motoo","family":"Shiro","sequence":"additional","affiliation":[{"name":"Rigaku Corporation  3-9-12 Matsubara-cho Akishima, Tokyo 196-8666 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norio","family":"Shibata","sequence":"additional","affiliation":[{"name":"Department of Frontier Materials Nagoya Institute of Technology, Gokiso  Showa-ku, Nagoya 466-8555 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,10,21]]},"reference":[{"key":"e_1_2_2_1_1","unstructured":"\u00a0"},{"key":"e_1_2_2_2_2","doi-asserted-by":"publisher","DOI":"10.1021\/cr800388c"},{"key":"e_1_2_2_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201205260"},{"key":"e_1_2_2_3_3","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201205260"},{"key":"e_1_2_2_4_2","doi-asserted-by":"publisher","DOI":"10.1021\/cs4003244"},{"key":"e_1_2_2_5_2","doi-asserted-by":"publisher","DOI":"10.1021\/cr500257c"},{"key":"e_1_2_2_6_1","unstructured":"For recent reviews on C-H activation with transition metal catalysts:"},{"key":"e_1_2_2_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201203269"},{"key":"e_1_2_2_7_3","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201203269"},{"key":"e_1_2_2_8_2","doi-asserted-by":"publisher","DOI":"10.1021\/ar200185g"},{"key":"e_1_2_2_9_1","unstructured":"\u00a0"},{"key":"e_1_2_2_10_2","doi-asserted-by":"publisher","DOI":"10.1021\/ar9701777"},{"key":"e_1_2_2_11_2","doi-asserted-by":"publisher","DOI":"10.3390\/md8082301"},{"key":"e_1_2_2_12_2","doi-asserted-by":"publisher","DOI":"10.3390\/md13074044"},{"key":"e_1_2_2_13_1","unstructured":"\u00a0"},{"key":"e_1_2_2_14_2","first-page":"121","volume-title":"The Handbook of Environmental Chemistry, Vol.\u20053N","author":"Gribble G. 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