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These results strongly support the hypothesis that the antidiabetic activity of Cr<jats:sup>III<\/jats:sup> and the carcinogenicity of Cr<jats:sup>VI<\/jats:sup> compounds arise from similar mechanisms involving highly reactive Cr<jats:sup>VI<\/jats:sup> and Cr<jats:sup>V<\/jats:sup> intermediates, and highlight concerns over the safety of Cr<jats:sup>III<\/jats:sup> nutritional supplements.<\/jats:p>","DOI":"10.1002\/anie.201509065","type":"journal-article","created":{"date-parts":[[2015,12,22]],"date-time":"2015-12-22T16:20:02Z","timestamp":1450801202000},"page":"1742-1745","source":"Crossref","is-referenced-by-count":57,"title":["Carcinogenic Chromium(VI) Compounds Formed by Intracellular Oxidation of Chromium(III) Dietary Supplements by Adipocytes"],"prefix":"10.1002","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1599-7574","authenticated-orcid":false,"given":"Lindsay E.","family":"Wu","sequence":"first","affiliation":[{"name":"School of Chemistry The University of Sydney  NSW 2006 Australia"},{"name":"Garvan Institute of Medical Research  384 Victoria St Darlinghurst NSW 2010 Australia"},{"name":"School of Medical Sciences UNSW Australia  NSW 2052 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aviva","family":"Levina","sequence":"additional","affiliation":[{"name":"School of Chemistry The University of Sydney  NSW 2006 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3472-8628","authenticated-orcid":false,"given":"Hugh H.","family":"Harris","sequence":"additional","affiliation":[{"name":"School of Chemistry The University of Sydney  NSW 2006 Australia"},{"name":"School of Chemistry and Physics The University of Adelaide  SA 5005 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhonghou","family":"Cai","sequence":"additional","affiliation":[{"name":"Advanced Photon Source X-ray Science Division Argonne National Laboratory  Argonne IL 60439 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barry","family":"Lai","sequence":"additional","affiliation":[{"name":"Advanced Photon Source X-ray Science Division Argonne National Laboratory  Argonne IL 60439 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8034-5513","authenticated-orcid":false,"given":"Stefan","family":"Vogt","sequence":"additional","affiliation":[{"name":"Advanced Photon Source X-ray Science Division Argonne National Laboratory  Argonne IL 60439 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David E.","family":"James","sequence":"additional","affiliation":[{"name":"Garvan Institute of Medical Research  384 Victoria St Darlinghurst NSW 2010 Australia"},{"name":"Charles Perkins Centre The University of Sydney  NSW 2006 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3232-2720","authenticated-orcid":false,"given":"Peter A.","family":"Lay","sequence":"additional","affiliation":[{"name":"School of Chemistry The University of Sydney  NSW 2006 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,12,22]]},"reference":[{"key":"e_1_2_2_1_1","unstructured":"\u00a0"},{"key":"e_1_2_2_2_2","volume-title":"The Nutritional Biochemistry of Chromium(III)","year":"2007"},{"key":"e_1_2_2_3_2","volume-title":"Dietary Supplements","author":"Mason P.","year":"2011"},{"key":"e_1_2_2_4_1","unstructured":"\u00a0"},{"key":"e_1_2_2_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/biof.5520110301"},{"key":"e_1_2_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-044453071-4\/50004-7"},{"key":"e_1_2_2_7_1","unstructured":"\u00a0"},{"key":"e_1_2_2_8_2","doi-asserted-by":"publisher","DOI":"10.1039\/b920480f"},{"key":"e_1_2_2_9_2","volume-title":"The Bioinorganic Chemistry of Chromium","author":"Vincent J. 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