{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T03:06:23Z","timestamp":1784603183605,"version":"3.55.0"},"reference-count":49,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,12,11]],"date-time":"2015-12-11T00:00:00Z","timestamp":1449792000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["306793"],"award-info":[{"award-number":["306793"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Angew Chem Int Ed"],"published-print":{"date-parts":[[2016,1,22]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Decagram quantities of enantiopure (+)\u2010mefloquine have been produced via kinetic resolution of racemic mefloquine using a ROMP\u2010gel supported chiral acyl hydroxamic acid resolving agent. The requisite monomer was prepared in a few synthetic steps without chromatography and polymerization was safely performed on a &gt;30\u2005gram scale under ambient conditions. The reagent was readily regenerated and reused multiple times for the resolution of 150\u2005grams of (\u00b1)\u2010mefloquine and other chiral N\u2010heterocylces.<\/jats:p>","DOI":"10.1002\/anie.201509256","type":"journal-article","created":{"date-parts":[[2015,12,11]],"date-time":"2015-12-11T13:40:33Z","timestamp":1449841233000},"page":"1553-1556","source":"Crossref","is-referenced-by-count":22,"title":["A Robust, Recyclable Resin for Decagram Scale Resolution of (<i>\u00b1<\/i>)\u2010Mefloquine and Other Chiral N\u2010Heterocycles"],"prefix":"10.1002","volume":"55","author":[{"given":"Imants","family":"Kreituss","sequence":"first","affiliation":[{"name":"Laboratorium f\u00fcr Organische Chemie, Departement Chemie und Angewandte Biowissenschaften ETH Z\u00fcrich  Vladimir-Prelog-Weg 3 CH-8093 Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuang\u2010Yen","family":"Chen","sequence":"additional","affiliation":[{"name":"Laboratorium f\u00fcr Organische Chemie, Departement Chemie und Angewandte Biowissenschaften ETH Z\u00fcrich  Vladimir-Prelog-Weg 3 CH-8093 Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon H.","family":"Eitel","sequence":"additional","affiliation":[{"name":"Roche Pharma Research and Early Development preclinical CMC, Roche Innovation Center Basel F. Hoffmann-La Roche Ltd  Grenzacherstrasse 124 CH-4070 Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Michel","family":"Adam","sequence":"additional","affiliation":[{"name":"Roche Pharma Research and Early Development preclinical CMC, Roche Innovation Center Basel F. Hoffmann-La Roche Ltd  Grenzacherstrasse 124 CH-4070 Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg","family":"Wuitschik","sequence":"additional","affiliation":[{"name":"F. Hoffmann-La Roche Ltd PTDCA, Process Research &amp; Development  Bldg 65\/618\u2005A CH-4070 Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alec","family":"Fettes","sequence":"additional","affiliation":[{"name":"F. Hoffmann-La Roche Ltd PTDCA, Process Research &amp; Development  Bldg 65\/618\u2005A CH-4070 Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey W.","family":"Bode","sequence":"additional","affiliation":[{"name":"Laboratorium f\u00fcr Organische Chemie, Departement Chemie und Angewandte Biowissenschaften ETH Z\u00fcrich  Vladimir-Prelog-Weg 3 CH-8093 Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,12,11]]},"reference":[{"key":"e_1_2_2_1_1","unstructured":"http:\/\/www.fda.gov\/Drugs\/InformationOnDrugs\/ApprovedDrugs\/(Accessed October2015)."},{"key":"e_1_2_2_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/op400233z"},{"key":"e_1_2_2_3_1","unstructured":"\u00a0"},{"key":"e_1_2_2_4_2","doi-asserted-by":"publisher","DOI":"10.1021\/op5003402"},{"key":"e_1_2_2_5_2","doi-asserted-by":"publisher","DOI":"10.1021\/op2000783"},{"key":"e_1_2_2_6_2","doi-asserted-by":"publisher","DOI":"10.1021\/op500170d"},{"key":"e_1_2_2_7_1","unstructured":"\u00a0"},{"key":"e_1_2_2_8_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja209472h"},{"key":"e_1_2_2_9_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja505784w"},{"key":"e_1_2_2_10_2","doi-asserted-by":"publisher","DOI":"10.1039\/c2cc34907h"},{"key":"e_1_2_2_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/1521-3773(20010105)40:1<234::AID-ANIE234>3.0.CO;2-K"},{"key":"e_1_2_2_11_3","doi-asserted-by":"publisher","DOI":"10.1002\/1521-3757(20010105)113:1<240::AID-ANGE240>3.0.CO;2-E"},{"key":"e_1_2_2_12_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja9079435"},{"key":"e_1_2_2_13_2","doi-asserted-by":"publisher","DOI":"10.1021\/ol301155b"},{"key":"e_1_2_2_14_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5b00190"},{"key":"e_1_2_2_15_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja306766n"},{"key":"e_1_2_2_16_1","unstructured":"\u00a0"},{"key":"e_1_2_2_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201204991"},{"key":"e_1_2_2_17_3","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201204991"},{"key":"e_1_2_2_18_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja984410n"},{"key":"e_1_2_2_19_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja000692r"},{"key":"e_1_2_2_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/chem.200500786"},{"key":"e_1_2_2_21_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja0035405"},{"key":"e_1_2_2_22_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja981447z"},{"key":"e_1_2_2_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201300258"},{"key":"e_1_2_2_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201300258"},{"key":"e_1_2_2_24_1","unstructured":"Guidelines for the Treatment of Malaria\u201c.World Health Organization 2015.http:\/\/apps.who.int\/iris\/bitstream\/10665\/162441\/1\/9789241549127_eng.pdf?ua=1&ua=1(accessed October 2015)."},{"key":"e_1_2_2_25_1","unstructured":"\u00a0"},{"key":"e_1_2_2_26_2","unstructured":"A.Fletcher R.Sheperd United States Patent. US 6 664 397 B1 2003;"},{"key":"e_1_2_2_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201303931"},{"key":"e_1_2_2_27_3","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201303931"},{"key":"e_1_2_2_28_2","unstructured":"E.\u2005J. Rastelli D.\u2005M. Coltart Angew. Chem. Int. Ed.2015 DOI:10.1002\/anie.201507304;Angew. Chem.2015 DOI:10.1002\/ange.201507304;"},{"key":"e_1_2_2_29_2","doi-asserted-by":"publisher","DOI":"10.1021\/op200354f"},{"key":"e_1_2_2_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/9780470147276.ch4"},{"key":"e_1_2_2_31_1","unstructured":"\u00a0"},{"key":"e_1_2_2_32_2","doi-asserted-by":"publisher","DOI":"10.1021\/cr0103423"},{"key":"e_1_2_2_33_2","doi-asserted-by":"publisher","DOI":"10.1021\/ol991208w"},{"key":"e_1_2_2_34_2","doi-asserted-by":"publisher","DOI":"10.1021\/ar000114f"},{"key":"e_1_2_2_35_2","doi-asserted-by":"publisher","DOI":"10.1021\/jo049827s"},{"key":"e_1_2_2_36_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja802010d"},{"key":"e_1_2_2_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.200601183"},{"key":"e_1_2_2_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/1521-3773(20021104)41:21<4035::AID-ANIE4035>3.0.CO;2-I"},{"key":"e_1_2_2_38_2","doi-asserted-by":"publisher","DOI":"10.1002\/1521-3757(20021104)114:21<4207::AID-ANGE4207>3.0.CO;2-G"},{"key":"e_1_2_2_39_1","unstructured":"Resolutions of (\u00b1)-mefloquine via diastereomeric salt formation have been reported; see:"},{"key":"e_1_2_2_40_2","unstructured":"A. D.Baxter M. J.Harris S.Brown International Patent Publication 2004 WO 2004\/050625 A1;"},{"key":"e_1_2_2_41_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm00248a015"},{"key":"e_1_2_2_42_2","doi-asserted-by":"publisher","DOI":"10.1351\/pac199668010131"},{"key":"e_1_2_2_43_2","doi-asserted-by":"publisher","DOI":"10.1021\/ol0360795"},{"key":"e_1_2_2_44_2","unstructured":"E.Brober W.Hofneinz A.Meili (Hoffmann-La\u2005Roche) Eur. Pat. 553778 1993; see also Ref.\u2005[8d]."}],"container-title":["Angewandte Chemie International Edition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fanie.201509256","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fanie.201509256","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anie.201509256","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T18:15:54Z","timestamp":1696616154000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/anie.201509256"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12,11]]},"references-count":49,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,1,22]]}},"alternative-id":["10.1002\/anie.201509256"],"URL":"https:\/\/doi.org\/10.1002\/anie.201509256","archive":["Portico"],"relation":{},"ISSN":["1433-7851","1521-3773"],"issn-type":[{"value":"1433-7851","type":"print"},{"value":"1521-3773","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,12,11]]}}}