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Enigmazole\u2005A interferes with c\u2010Kit signaling by an as yet unknown mode of action and is therefore a potential lead in the quest for novel anticancer agents. Key to success is a gold\u2010catalyzed cascade comprising a [3,3]\u2010sigmatropic rearrangement of a propargyl acetate along the periphery of a macrocyclic scaffold, followed by a transannular hydroalkoxylation of the resulting transient allenyl acetate. This transformation mandated the use of a chiral gold catalyst to ensure a matching double\u2010asymmetric setting. Other noteworthy steps are the preparation of the oxazole building block by a palladium\u2010catalyzed C\u2212H activation, as well as the smooth ring\u2010closing alkyne metathesis of a diyne substrate bearing a propargylic leaving group, which has only little precedent.<\/jats:p>","DOI":"10.1002\/anie.201510026","type":"journal-article","created":{"date-parts":[[2015,12,13]],"date-time":"2015-12-13T04:55:52Z","timestamp":1449982552000},"page":"1406-1411","source":"Crossref","is-referenced-by-count":96,"title":["Concise Total Synthesis of Enigmazole\u2005A"],"prefix":"10.1002","volume":"55","author":[{"given":"Andreas","family":"Ahlers","sequence":"first","affiliation":[{"name":"Max-Planck-Institut f\u00fcr Kohlenforschung  45470 M\u00fclheim\/Ruhr Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"de\u2005Haro","sequence":"additional","affiliation":[{"name":"Max-Planck-Institut f\u00fcr Kohlenforschung  45470 M\u00fclheim\/Ruhr Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Gabor","sequence":"additional","affiliation":[{"name":"Max-Planck-Institut f\u00fcr Kohlenforschung  45470 M\u00fclheim\/Ruhr Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alois","family":"F\u00fcrstner","sequence":"additional","affiliation":[{"name":"Max-Planck-Institut f\u00fcr Kohlenforschung  45470 M\u00fclheim\/Ruhr Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,12,10]]},"reference":[{"key":"e_1_2_2_1_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja1016766"},{"key":"e_1_2_2_2_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.6087"},{"key":"e_1_2_2_3_1","first-page":"357027","author":"Iqbal N.","year":"2014","journal-title":"Chemother. 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