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In this work, a highly efficient one\u2010pot reaction between P<jats:sub>4<\/jats:sub> and 1,4\u2010dilithio\u20101,3\u2010butadienes was realized, which quantitatively affords phospholyl lithium derivatives. DFT calculations indicate that the mechanism is significantly different from that of the well\u2010known stepwise cleavage of P\u2212P bond in P<jats:sub>4<\/jats:sub> activation. Instead, a cooperative nucleophilic attack of two C<jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/anie201602790-math-0001.png\" xlink:title=\"urn:x-wiley:14337851:media:anie201602790:anie201602790-math-0001\"\/>\nLi bonds on P<jats:sub>4<\/jats:sub>, leading to simultaneous cleavage of two P\u2212P bonds, is favorable. This mechanistic information offers a new view on the mechanism of P<jats:sub>4<\/jats:sub> activation, as well as a reasonable explanation for the excellent yields and selectivity. This method could prove to be a useful route to P<jats:sub>4<\/jats:sub> activation and the subsequent production of organophosphorus compounds.<\/jats:p>","DOI":"10.1002\/anie.201602790","type":"journal-article","created":{"date-parts":[[2016,6,15]],"date-time":"2016-06-15T18:29:31Z","timestamp":1466015371000},"page":"9187-9190","source":"Crossref","is-referenced-by-count":83,"title":["Direct Synthesis of Phospholyl Lithium from White Phosphorus"],"prefix":"10.1002","volume":"55","author":[{"given":"Ling","family":"Xu","sequence":"first","affiliation":[{"name":"Beijing National Laboratory for Molecular Sciences (BNLMS), Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry Peking University  Beijing 100871 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Chi","sequence":"additional","affiliation":[{"name":"Beijing National Laboratory for Molecular Sciences (BNLMS), Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry Peking University  Beijing 100871 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanshan","family":"Du","sequence":"additional","affiliation":[{"name":"Beijing National Laboratory for Molecular Sciences (BNLMS), Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry Peking University  Beijing 100871 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen\u2010Xiong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Beijing National Laboratory for Molecular Sciences (BNLMS), Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry Peking University  Beijing 100871 China"},{"name":"State Key Laboratory of Elemento-Organic Chemistry Nankai University  Tianjin 300071 P.R. 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