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However, the efficient detection and imaging of H<jats:sub>2<\/jats:sub>S in live animals is very challenging. Herein, we report the first radioisotope\u2010based immobilization technique for the detection, quantification, and in vivo imaging of endogenous H<jats:sub>2<\/jats:sub>S. Macrocyclic <jats:sup>64<\/jats:sup>Cu complexes that instantly reacted with gaseous H<jats:sub>2<\/jats:sub>S to form insoluble <jats:sup>64<\/jats:sup>CuS in a highly sensitive and selective manner were prepared. The H<jats:sub>2<\/jats:sub>S concentration in biological samples was measured by a thin\u2010layer radiochromatography method. When <jats:sup>64<\/jats:sup>Cu\u2013cyclen was injected into mice, an elevated H<jats:sub>2<\/jats:sub>S concentration in the inflamed paw was clearly visualized and quantified by Cerenkov luminescence and positron emission tomography (PET) imaging. PET imaging was also able to pinpoint increased H<jats:sub>2<\/jats:sub>S levels in a millimeter\u2010sized infarcted lesion of the rat heart.<\/jats:p>","DOI":"10.1002\/anie.201603813","type":"journal-article","created":{"date-parts":[[2016,7,8]],"date-time":"2016-07-08T11:37:43Z","timestamp":1467977863000},"page":"9365-9370","source":"Crossref","is-referenced-by-count":37,"title":["Immobilization of the Gas Signaling Molecule H<sub>2<\/sub>S by Radioisotopes: Detection, Quantification, and In Vivo Imaging"],"prefix":"10.1002","volume":"55","author":[{"given":"Swarbhanu","family":"Sarkar","sequence":"first","affiliation":[{"name":"Department of Molecular Medicine Department of Anatomy, BK21 Plus Program Kyungpook National University  Daegu 41944 Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yeong Su","family":"Ha","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine Department of Anatomy, BK21 Plus Program Kyungpook National 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