{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T18:52:29Z","timestamp":1791831149326,"version":"4.3.4"},"reference-count":48,"publisher":"Wiley","issue":"31","license":[{"start":{"date-parts":[[2016,6,17]],"date-time":"2016-06-17T00:00:00Z","timestamp":1466121600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"DGICYT-Spain","award":["CTQ-2015-67870P"],"award-info":[{"award-number":["CTQ-2015-67870P"]}]},{"name":"DGICYT-Spain","award":["SAF2014-57094R"],"award-info":[{"award-number":["SAF2014-57094R"]}]},{"DOI":"10.13039\/501100002809","name":"Generalitat de Catalunya","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"CONACyT-M\u00e9xico","award":["CB-2011-166747-Q"],"award-info":[{"award-number":["CB-2011-166747-Q"]}]},{"name":"CONACYT","award":["481808"],"award-info":[{"award-number":["481808"]}]},{"name":"CONACYT","award":["285150"],"award-info":[{"award-number":["285150"]}]},{"name":"Icrea Academia"},{"name":"Consorci de Serveis Universitaris de Catalunya"},{"DOI":"10.13039\/501100014054","name":"Drugs for Neglected Diseases Initiative","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100014054","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Angew Chem Int Ed"],"published-print":{"date-parts":[[2016,7,25]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Trimethylsilyl chloride is an efficient activating agent for azines in isocyanide\u2010based reactions, which then proceed through a key insertion of the isocyanide into a N\u2212Si bond. The reaction is initiated by N\u2005activation of the azine, followed by nucleophilic attack of an isocyanide in a Reissert\u2010type process. Finally, a second equivalent of the same or a different isocyanide inserts into the N\u2212Si bond leading to the final adduct. The use of distinct nucleophiles leads to a variety of \u03b1\u2010substituted dihydroazines after a selective cascade process. Based on computational studies, a mechanistic hypothesis for the course of these reactions was proposed. The resulting products exhibit significant activity against <jats:italic>Trypanosoma\u2005brucei<\/jats:italic> and <jats:italic>T.\u2005cruzi<\/jats:italic>, featuring favorable drug\u2010like properties and safety profiles.<\/jats:p>","DOI":"10.1002\/anie.201604109","type":"journal-article","created":{"date-parts":[[2016,6,17]],"date-time":"2016-06-17T15:03:01Z","timestamp":1466175781000},"page":"8994-8998","source":"Crossref","is-referenced-by-count":37,"title":["Insertion of Isocyanides into N\u2212Si Bonds: Multicomponent Reactions with Azines Leading to Potent Antiparasitic Compounds"],"prefix":"10.1002","volume":"55","author":[{"given":"Kranti G.","family":"Kishore","sequence":"first","affiliation":[{"name":"Departamento de Qu\u00edmica Universidad de Guanajuato, Noria Alta S\/N  CP 36050 Guanajuato, Gto. 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