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We applied a combination of kinetic experiments and molecular dynamics simulations to elucidate how (model) surfaces influence fibril formation of the amyloid\u2010forming sequences of prion protein SUP35 and human islet amyloid polypeptide. The kinetic data suggest that structural reorganization of the initial peptide corona around colloidal gold nanoparticles is the rate\u2010limiting step. The molecular dynamics simulations reveal that partial physisorption to the surface results in the formation of aligned monolayers, which stimulate the formation of parallel, critical oligomers. The general mechanism implies that the competition between the underlying peptide\u2013peptide and peptide\u2013surface interactions must strike a balance to accelerate fibril formation.<\/jats:p>","DOI":"10.1002\/anie.201605151","type":"journal-article","created":{"date-parts":[[2016,8,11]],"date-time":"2016-08-11T13:35:15Z","timestamp":1470922515000},"page":"11242-11246","source":"Crossref","is-referenced-by-count":91,"title":["Gold\u2010Induced Fibril Growth: The Mechanism of Surface\u2010Facilitated Amyloid Aggregation"],"prefix":"10.1002","volume":"55","author":[{"given":"Anika","family":"Gladytz","sequence":"first","affiliation":[{"name":"Chemistry Department Leibniz Institute of Surface Modification (IOM) Leipzig e.V.  Permoserstrasse 15 04318 Leipzig Germany"},{"name":"Faculty of Chemistry and Mineralogy University of Leipzig  Linn\u00e9strasse 3 04193 Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernd","family":"Abel","sequence":"additional","affiliation":[{"name":"Chemistry Department Leibniz Institute of Surface Modification (IOM) Leipzig e.V.  Permoserstrasse 15 04318 Leipzig Germany"},{"name":"Faculty of Chemistry and Mineralogy University of Leipzig  Linn\u00e9strasse 3 04193 Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herre Jelger","family":"Risselada","sequence":"additional","affiliation":[{"name":"Chemistry Department Leibniz Institute of Surface Modification (IOM) Leipzig e.V.  Permoserstrasse 15 04318 Leipzig Germany"},{"name":"Department of Theoretical Physics Georg-August-University  Friedrich-Hund-Platz 1 37077 G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,8,11]]},"reference":[{"key":"e_1_2_2_1_1","unstructured":"\u00a0"},{"key":"e_1_2_2_2_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0701250104"},{"key":"e_1_2_2_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201201068"},{"key":"e_1_2_2_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppsc.201400222"},{"key":"e_1_2_2_5_1","unstructured":"\u00a0"},{"key":"e_1_2_2_6_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.289.5483.1317"},{"key":"e_1_2_2_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.624"},{"key":"e_1_2_2_8_2","doi-asserted-by":"publisher","DOI":"10.1039\/C4CP03072A"},{"key":"e_1_2_2_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1000458"},{"key":"e_1_2_2_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr100440g"},{"key":"e_1_2_2_11_1","doi-asserted-by":"publisher","DOI":"10.1039\/c3nr33193h"},{"key":"e_1_2_2_12_1","unstructured":"\u00a0"},{"key":"e_1_2_2_13_2","doi-asserted-by":"publisher","DOI":"10.1039\/C5RA20182A"},{"key":"e_1_2_2_14_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja505502e"},{"key":"e_1_2_2_15_1","unstructured":"\u00a0"},{"key":"e_1_2_2_16_2","doi-asserted-by":"publisher","DOI":"10.1021\/nn506161j"},{"key":"e_1_2_2_17_2","doi-asserted-by":"publisher","DOI":"10.13052\/jsame2245-4551.211"},{"key":"e_1_2_2_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.21165"},{"key":"e_1_2_2_19_2","doi-asserted-by":"publisher","DOI":"10.1021\/la904765u"},{"key":"e_1_2_2_20_1","doi-asserted-by":"publisher","DOI":"10.1529\/biophysj.106.100537"},{"key":"e_1_2_2_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05695"},{"key":"e_1_2_2_22_1","doi-asserted-by":"publisher","DOI":"10.1063\/1.4755748"},{"key":"e_1_2_2_23_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.0020321"},{"key":"e_1_2_2_24_1","unstructured":"\u00a0"},{"key":"e_1_2_2_25_2","doi-asserted-by":"publisher","DOI":"10.1039\/C4NR01005A"},{"key":"e_1_2_2_26_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0065579"},{"key":"e_1_2_2_27_1","doi-asserted-by":"publisher","DOI":"10.1063\/1.3624929"}],"container-title":["Angewandte Chemie International Edition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fanie.201605151","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fanie.201605151","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anie.201605151","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T14:26:19Z","timestamp":1694615179000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/anie.201605151"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8,11]]},"references-count":27,"journal-issue":{"issue":"37","published-print":{"date-parts":[[2016,9,5]]}},"alternative-id":["10.1002\/anie.201605151"],"URL":"https:\/\/doi.org\/10.1002\/anie.201605151","archive":["Portico"],"relation":{},"ISSN":["1433-7851","1521-3773"],"issn-type":[{"value":"1433-7851","type":"print"},{"value":"1521-3773","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8,11]]}}}