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Key challenges associated with developing new chemical tools for understanding the biological roles of H<jats:sub>2<\/jats:sub>S include developing platforms that enable reversible binding of this important biomolecule. The first synthetic small molecule receptor for the hydrosulfide anion, HS<jats:sup>\u2212<\/jats:sup>, using only reversible, hydrogen\u2010bonding interactions in a series of bis(ethynylaniline) derivatives, is reported. Binding constants of up to 90\u2009300\u00b18700\u2009<jats:sc>m<\/jats:sc><jats:sup>\u22121<\/jats:sup> were obtained in MeCN. The fundamental science of reversible sulfide binding, in this case featuring a key CH\u22c5\u22c5\u22c5S hydrogen bond, will expand the possibility for discovery of sulfide protein targets and molecular recognition agents.<\/jats:p>","DOI":"10.1002\/anie.201605757","type":"journal-article","created":{"date-parts":[[2016,8,11]],"date-time":"2016-08-11T06:58:25Z","timestamp":1470898705000},"page":"11480-11484","source":"Crossref","is-referenced-by-count":47,"title":["A Synthetic Supramolecular Receptor for the Hydrosulfide Anion"],"prefix":"10.1002","volume":"55","author":[{"given":"Matthew D.","family":"Hartle","sequence":"first","affiliation":[{"name":"Department of Chemistry &amp; Biochemistry, Materials Science Institute, and Institute of Molecular Biology University of Oregon  Eugene OR 97403-1253 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryan J.","family":"Hansen","sequence":"additional","affiliation":[{"name":"Department of Chemistry &amp; Biochemistry, Materials Science Institute, and Institute of Molecular Biology University of Oregon  Eugene OR 97403-1253 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Blakely W.","family":"Tresca","sequence":"additional","affiliation":[{"name":"Department of Chemistry &amp; 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