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However, effective approaches that can probe the infection risk of influenza viruses for humans are rare. In this work, we develop a glycofoldamer that can rapidly identify the glycan\u2010receptor specificity of influenza viruses in a high\u2010throughput manner. The coupling of glycan receptors that can be recognized by hemagglutinin (a surface protein on the virion capsid of influenza) to a fluorogenic\u2010dye foldamer produces the glycofoldamers with minimal fluorescence in aqueous solution. After interaction with human\u2010infecting virus strains for only five minutes, the fluorescence intensity of the glycofoldamer is remarkably enhanced with a blue\u2010shifted emission peak. The probes have also proven effective for the rapid identification of 1)\u2005the human\u2010 or bird\u2010infecting properties of influenza viruses in a high\u2010throughput manner and 2)\u2005the receptor\u2010specificity switch of a virus strain by mutations.<\/jats:p>","DOI":"10.1002\/anie.201606488","type":"journal-article","created":{"date-parts":[[2016,8,11]],"date-time":"2016-08-11T13:33:17Z","timestamp":1470922397000},"page":"13995-13999","source":"Crossref","is-referenced-by-count":43,"title":["Rapid Identification of the Receptor\u2010Binding Specificity of Influenza\u2005A Viruses by Fluorogenic Glycofoldamers"],"prefix":"10.1002","volume":"55","author":[{"given":"Xiao\u2010Peng","family":"He","sequence":"first","affiliation":[{"name":"Key Laboratory for Advanced Materials &amp; Institute of Fine Chemicals School of Chemistry and Molecular Engineering East China University of Science and Technology  130 Meilong Rd. 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