{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T06:19:53Z","timestamp":1791353993746,"version":"4.3.1"},"reference-count":54,"publisher":"Wiley","issue":"47","license":[{"start":{"date-parts":[[2016,10,24]],"date-time":"2016-10-24T00:00:00Z","timestamp":1477267200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Angew Chem Int Ed"],"published-print":{"date-parts":[[2016,11,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Hydrogen sulfide (H\n                    <jats:sub>2<\/jats:sub>\n                    S) exhibits promising protective effects in many (patho)physiological processes, as evidenced by recent reports using synthetic H\n                    <jats:sub>2<\/jats:sub>\n                    S donors in different biological models. Herein, we report the design and evaluation of compounds denoted PeroxyTCM, which are the first class of reactive oxygen species (ROS)\u2010triggered H\n                    <jats:sub>2<\/jats:sub>\n                    S donors. These donors are engineered to release carbonyl sulfide (COS) upon activation, which is quickly hydrolyzed to H\n                    <jats:sub>2<\/jats:sub>\n                    S by the ubiquitous enzyme carbonic anhydrase (CA). The donors are stable in aqueous solution and do not release H\n                    <jats:sub>2<\/jats:sub>\n                    S until triggered by ROS, such as hydrogen peroxide (H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    ), superoxide (O\n                    <jats:sub>2<\/jats:sub>\n                    <jats:sup>\u2212<\/jats:sup>\n                    ), and peroxynitrite (ONOO\n                    <jats:sup>\u2212<\/jats:sup>\n                    ). We demonstrate ROS\u2010triggered H\n                    <jats:sub>2<\/jats:sub>\n                    S donation in live cells and also demonstrate that PeroxyTCM\u20101 provides protection against H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    \u2010induced oxidative damage, suggesting potential future applications of PeroxyTCM and similar scaffolds in H\n                    <jats:sub>2<\/jats:sub>\n                    S\u2010related therapies.\n                  <\/jats:p>","DOI":"10.1002\/anie.201608052","type":"journal-article","created":{"date-parts":[[2016,10,24]],"date-time":"2016-10-24T04:08:00Z","timestamp":1477282080000},"page":"14638-14642","source":"Crossref","is-referenced-by-count":180,"title":["Hydrogen Sulfide Donors Activated by Reactive Oxygen Species"],"prefix":"10.1002","volume":"55","author":[{"given":"Yu","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Chemistry and Biochemistry Institute of Molecular Biology, and Materials Science Institute University of Oregon  Eugene OR 97403 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3604-653X","authenticated-orcid":false,"given":"Michael D.","family":"Pluth","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry Institute of Molecular Biology, and Materials Science Institute University of Oregon  Eugene OR 97403 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,10,24]]},"reference":[{"key":"e_1_2_2_1_1","unstructured":"\u00a0"},{"key":"e_1_2_2_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2425"},{"key":"e_1_2_2_3_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00017.2011"},{"key":"e_1_2_2_4_1","unstructured":"\u00a0"},{"key":"e_1_2_2_5_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2013.5339"},{"key":"e_1_2_2_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3391"},{"key":"e_1_2_2_7_1","unstructured":"\u00a0"},{"key":"e_1_2_2_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.114.300505"},{"key":"e_1_2_2_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd4433"},{"key":"e_1_2_2_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/20.21.6008"},{"key":"e_1_2_2_11_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2009.04.012"},{"key":"e_1_2_2_12_1","unstructured":"\u00a0"},{"key":"e_1_2_2_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00726-007-0011-8"},{"key":"e_1_2_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2004.04.094"},{"key":"e_1_2_2_15_1","unstructured":"\u00a0"},{"key":"e_1_2_2_16_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2009.2882"},{"key":"e_1_2_2_17_2","doi-asserted-by":"publisher","DOI":"10.1586\/ecp.10.56"},{"key":"e_1_2_2_18_1","unstructured":"\u00a0"},{"key":"e_1_2_2_19_2","unstructured":"M.\u2005D. 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