{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T07:38:42Z","timestamp":1792136322083,"version":"4.4.0"},"reference-count":85,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,12,30]],"date-time":"2016-12-30T00:00:00Z","timestamp":1483056000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Angew Chem Int Ed"],"published-print":{"date-parts":[[2017,1,19]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A highly enantioselective regiodivergent addition of alkoxyallenes to pyrazolones was developed to afford multiply functionalized alkylated products bearing a quaternary carbon stereocenter in high yields with excellent stereoselectivities. One approach is enabled by palladium catalysis, thus leading to branched allylic pyrazol\u20105\u2010ones under mild reaction conditions. The other is catalyzed by a chiral Br\u00f8nsted acid to give linear products exclusively. Moreover, the usefulness of this new method was highlighted by converting the allylic products into other interesting multifunctionalized pyrazolone derivatives which would be of great potential for the exploitation of pharmaceutically important molecules.<\/jats:p>","DOI":"10.1002\/anie.201610473","type":"journal-article","created":{"date-parts":[[2016,12,30]],"date-time":"2016-12-30T10:22:52Z","timestamp":1483093372000},"page":"1077-1081","source":"Crossref","is-referenced-by-count":92,"title":["From Palladium to Br\u00f8nsted Acid Catalysis: Highly Enantioselective Regiodivergent Addition of Alkoxyallenes to Pyrazolones"],"prefix":"10.1002","volume":"56","author":[{"given":"Hui","family":"Zhou","sequence":"first","affiliation":[{"name":"State Key Laboratory for Oxo Synthesis and Selective Oxidation Suzhou Research Institute of LICP Lanzhou Institute of Chemical Physics (LICP) Chinese Academy of Sciences (CAS)  Lanzhou 730000 P.R. China"},{"name":"University of Chinese Academy of Sciences  Beijing 100049 P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhao","family":"Wei","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Oxo Synthesis and Selective Oxidation Suzhou Research Institute of LICP Lanzhou Institute of Chemical Physics (LICP) Chinese Academy of Sciences (CAS)  Lanzhou 730000 P.R. China"},{"name":"University of Chinese Academy of Sciences  Beijing 100049 P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinlong","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Oxo Synthesis and Selective Oxidation Suzhou Research Institute of LICP Lanzhou Institute of Chemical Physics (LICP) Chinese Academy of Sciences (CAS)  Lanzhou 730000 P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huameng","family":"Yang","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Oxo Synthesis and Selective Oxidation Suzhou Research Institute of LICP Lanzhou Institute of Chemical Physics (LICP) Chinese Academy of Sciences (CAS)  Lanzhou 730000 P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chungu","family":"Xia","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Oxo Synthesis and Selective Oxidation Suzhou Research Institute of LICP Lanzhou Institute of Chemical Physics (LICP) Chinese Academy of Sciences (CAS)  Lanzhou 730000 P.R. 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,12,30]]},"reference":[{"key":"e_1_2_2_1_1","unstructured":"\u00a0"},{"key":"e_1_2_2_2_2","volume-title":"Comprehensive Asymmetric Catalysis","year":"1999"},{"key":"e_1_2_2_3_2","volume-title":"Transition Metals in Organic Synthesis: A Practical Approach","year":"1997"},{"key":"e_1_2_2_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/9783527628841.ch7"},{"key":"e_1_2_2_5_1","unstructured":"For selected reviews see:"},{"key":"e_1_2_2_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201201787"},{"key":"e_1_2_2_6_3","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201201787"},{"key":"e_1_2_2_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200901317"},{"key":"e_1_2_2_7_3","doi-asserted-by":"publisher","DOI":"10.1002\/ange.200901317"},{"key":"e_1_2_2_8_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1180739"},{"key":"e_1_2_2_9_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja303115m"},{"key":"e_1_2_2_10_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja509077a"},{"key":"e_1_2_2_11_1","unstructured":"\u00a0"},{"key":"e_1_2_2_12_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1962206"},{"key":"e_1_2_2_13_2","doi-asserted-by":"publisher","DOI":"10.1039\/b804163f"},{"key":"e_1_2_2_14_2","doi-asserted-by":"publisher","DOI":"10.1039\/B918763B"},{"key":"e_1_2_2_15_1","unstructured":"For a book on pyrazolone chemistry see:"},{"key":"e_1_2_2_16_2","first-page":"143","volume-title":"Advances in Heterocyclic Chemistry, Vol.\u200598","author":"Varvounis G.","year":"2009"},{"key":"e_1_2_2_17_2","doi-asserted-by":"publisher","DOI":"10.1021\/cr020033s"},{"key":"e_1_2_2_18_1","unstructured":"\u00a0"},{"key":"e_1_2_2_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1948.tb27246.x"},{"key":"e_1_2_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1366-0071(97)80033-2"},{"key":"e_1_2_2_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/jhet.5570440108"},{"key":"e_1_2_2_22_2","volume-title":"\u201cDipyrone\u201d. 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