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This strategy is based on two closely related approaches involving the late\u2010stage installation of the isomerization\u2010prone (2<jats:italic>Z<\/jats:italic>,4<jats:italic>E<\/jats:italic>,6<jats:italic>Z<\/jats:italic>,8<jats:italic>E<\/jats:italic>)\u2010tetraenoate motif, and an expedient fragment\u2010assembly procedure. The result is a highly convergent total synthesis of chivosazole\u2005F through the orchestration of three mild Pd\/Cu\u2010mediated Stille cross\u2010coupling reactions, including the use of a one\u2010pot, site\u2010selective, three\u2010component process, in combination with controlled installation of the requisite alkene geometry.<\/jats:p>","DOI":"10.1002\/anie.201610636","type":"journal-article","created":{"date-parts":[[2016,11,29]],"date-time":"2016-11-29T10:13:56Z","timestamp":1480414436000},"page":"645-649","source":"Crossref","is-referenced-by-count":29,"title":["An Expedient Total Synthesis of Chivosazole\u2005F: an Actin\u2010Binding Antimitotic Macrolide from the Myxobacterium <i>Sorangium Cellulosum<\/i>"],"prefix":"10.1002","volume":"56","author":[{"given":"Simon","family":"Williams","sequence":"first","affiliation":[{"name":"University Chemical Laboratory University of Cambridge  Lensfield Road Cambridge CB2 1EW UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jialu","family":"Jin","sequence":"additional","affiliation":[{"name":"University Chemical Laboratory University of Cambridge  Lensfield Road Cambridge CB2 1EW UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. 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Jennifer","family":"Kan","sequence":"additional","affiliation":[{"name":"University Chemical Laboratory University of Cambridge  Lensfield Road Cambridge CB2 1EW UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mungyuen","family":"Li","sequence":"additional","affiliation":[{"name":"University Chemical Laboratory University of Cambridge  Lensfield Road Cambridge CB2 1EW UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa J.","family":"Gibson","sequence":"additional","affiliation":[{"name":"University Chemical Laboratory University of Cambridge  Lensfield Road Cambridge CB2 1EW UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian","family":"Paterson","sequence":"additional","affiliation":[{"name":"University Chemical Laboratory University of Cambridge  Lensfield Road Cambridge CB2 1EW UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,11,29]]},"reference":[{"key":"e_1_2_2_1_1","unstructured":"\u00a0"},{"key":"e_1_2_2_2_2","doi-asserted-by":"publisher","DOI":"10.7164\/antibiotics.48.962"},{"key":"e_1_2_2_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/jlac.199719970814"},{"key":"e_1_2_2_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/cbic.200900562"},{"key":"e_1_2_2_5_1","unstructured":"\u00a0"},{"key":"e_1_2_2_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200290057"},{"key":"e_1_2_2_6_3","doi-asserted-by":"publisher","DOI":"10.1002\/ange.200290059"},{"key":"e_1_2_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbcan.2014.09.007"},{"key":"e_1_2_2_8_1","unstructured":"\u00a0"},{"key":"e_1_2_2_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-006-6157-9"},{"key":"e_1_2_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2008.01.010"},{"key":"e_1_2_2_11_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja406580w"},{"key":"e_1_2_2_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200605198"},{"key":"e_1_2_2_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/ange.200605198"},{"key":"e_1_2_2_13_1","unstructured":"\u00a0"},{"key":"e_1_2_2_14_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja107290s"},{"key":"e_1_2_2_15_2","first-page":"2667","author":"Janssen D.","year":"2007","journal-title":"Synlett"},{"key":"e_1_2_2_16_1","unstructured":"\u00a0"},{"key":"e_1_2_2_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201301978"},{"key":"e_1_2_2_17_3","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201301978"},{"key":"e_1_2_2_18_2","doi-asserted-by":"publisher","DOI":"10.1021\/ol401327r"},{"key":"e_1_2_2_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/asia.200700357"},{"key":"e_1_2_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/0040-4020(95)00549-N"},{"key":"e_1_2_2_21_1","unstructured":"\u00a0"},{"key":"e_1_2_2_22_2","doi-asserted-by":"publisher","DOI":"10.1021\/ol101630p"},{"key":"e_1_2_2_23_2","doi-asserted-by":"publisher","DOI":"10.1021\/ol102425n"},{"key":"e_1_2_2_24_1","unstructured":"\u00a0"},{"key":"e_1_2_2_25_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja00237a029"},{"key":"e_1_2_2_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.198605081"},{"key":"e_1_2_2_26_3","doi-asserted-by":"publisher","DOI":"10.1002\/ange.19860980605"},{"key":"e_1_2_2_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200500368"},{"key":"e_1_2_2_27_3","doi-asserted-by":"publisher","DOI":"10.1002\/ange.200500368"},{"key":"e_1_2_2_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tet.2013.07.108"},{"key":"e_1_2_2_29_1","unstructured":"\u00a0"},{"key":"e_1_2_2_30_2","doi-asserted-by":"publisher","DOI":"10.1039\/a608187h"},{"key":"e_1_2_2_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tet.2007.01.048"},{"key":"e_1_2_2_32_1","doi-asserted-by":"publisher","DOI":"10.1021\/ol100693c"},{"key":"e_1_2_2_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4020(01)85588-5"},{"key":"e_1_2_2_34_1","unstructured":"Reviews of asymmetric boron-mediated aldol reactions:"},{"key":"e_1_2_2_35_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201303914"},{"key":"e_1_2_2_35_3","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201303914"},{"key":"e_1_2_2_36_2","first-page":"1","volume":"51","author":"Cowden C. 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