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In the reaction, it may be conceivable that the handedness of amino acids has been determined at the formation stage of the chiral intermediate \u03b1\u2010aminonitrile, that is, the enantioselective addition of hydrogen cyanide to an imine. Herein, an enantiotopic crystal surface of an achiral imine acted as an origin of chirality for the enantioselective formation of \u03b1\u2010aminonitriles by the addition of HCN. In conjunction with the amplification of the enantiomeric excess and multiplication of enantioenriched aminonitrile, a large amount of near enantiopure \u03b1\u2010amino acids, with the <jats:italic><jats:sc>l<\/jats:sc><\/jats:italic>\u2010 and <jats:italic><jats:sc>d<\/jats:sc><\/jats:italic>\u2010handedness corresponding to the molecular orientation of the imine, is reported.<\/jats:p>","DOI":"10.1002\/anie.201611128","type":"journal-article","created":{"date-parts":[[2016,12,22]],"date-time":"2016-12-22T12:49:14Z","timestamp":1482410954000},"page":"1055-1058","source":"Crossref","is-referenced-by-count":40,"title":["Asymmetric Strecker Reaction Arising from the Molecular Orientation of an Achiral Imine at the Single\u2010Crystal Face: Enantioenriched <scp>l<\/scp>\u2010 and <scp>d<\/scp>\u2010Amino Acids"],"prefix":"10.1002","volume":"56","author":[{"given":"Shinobu","family":"Miyagawa","sequence":"first","affiliation":[{"name":"Department of Materials Science University of Fukui  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