{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T09:23:07Z","timestamp":1787563387704,"version":"build-2736575974"},"reference-count":75,"publisher":"Wiley","issue":"15","license":[{"start":{"date-parts":[[2017,3,27]],"date-time":"2017-03-27T00:00:00Z","timestamp":1490572800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100012352","name":"Universit\u00e0 degli Studi di Milano","doi-asserted-by":"crossref","award":["H2020 - Transition grant"],"award-info":[{"award-number":["H2020 - Transition grant"]}],"id":[{"id":"10.13039\/100012352","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Angew Chem Int Ed"],"published-print":{"date-parts":[[2017,4,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    3D\u2010printed flow reactors were designed, fabricated from different materials (PLA, HIPS, nylon), and used for a catalytic stereoselective Henry reaction. The use of readily prepared and tunable 3D\u2010printed reactors enabled the rapid screening of devices with different sizes, shapes, and channel dimensions, aimed at the identification of the best\u2010performing reactor setup. The optimized process afforded the products in high yields, moderate diastereoselectivity, and up to 90\u2009%\n                    <jats:italic>ee<\/jats:italic>\n                    . The method was applied to the continuous\u2010flow synthesis of biologically active chiral 1,2\u2010amino alcohols (norephedrine, metaraminol, and methoxamine) through a two\u2010step sequence combining the nitroaldol reaction with a hydrogenation. To highlight potential industrial applications of this method, a multistep continuous synthesis of norephedrine has been realized. The product was isolated without any intermediate purifications or solvent switches.\n                  <\/jats:p>","DOI":"10.1002\/anie.201612192","type":"journal-article","created":{"date-parts":[[2017,3,27]],"date-time":"2017-03-27T03:06:56Z","timestamp":1490584016000},"page":"4290-4294","source":"Crossref","is-referenced-by-count":73,"title":["Stereoselective Catalytic Synthesis of Active Pharmaceutical Ingredients in Homemade 3D\u2010Printed Mesoreactors"],"prefix":"10.1002","volume":"56","author":[{"given":"Sergio","family":"Rossi","sequence":"first","affiliation":[{"name":"Dipartimento di Chimica Universit\u00e0 degli Studi di Milano  Via C. Golgi, 19 20133 Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo","family":"Porta","sequence":"additional","affiliation":[{"name":"Dipartimento di Chimica Universit\u00e0 degli Studi di Milano  Via C. 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