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However, expanding its use to include high\u2010dose treatment of other cancers is severely hampered by serious side effects on healthy organs. To address these limitations, we loaded ATO onto folate (FA)\u2010labeled human serum albumin (HSA) pretreated with glutathione (GSH) based on the low pH\u2010 and GSH\u2010sensitive arsenic\u2010sulfur bond, and we termed the resulting smart nanodrug as FA\u2010HSA\u2010ATO. FA\u2010HSA\u2010ATO could specifically recognize folate receptor\u2010\u03b2\u2010positive (FR\u03b2+) chronic myeloid leukemia (CML) cells, resulting in more intracellular accumulation of ATO. Furthermore, the nanodrug could upregulate FR\u03b2 expression in CML cancer cells and xenograft tumor model, facilitating even more recruitment and uptake of FR\u03b2\u2010targeting drugs. In\u2005vitro and in\u2005vivo experiments indicate that the nanodrug significantly alleviates side effects and improves therapeutic efficacy of ATO on CML and xenograft tumor model.\n                  <\/jats:p>","DOI":"10.1002\/anie.201701366","type":"journal-article","created":{"date-parts":[[2017,7,7]],"date-time":"2017-07-07T12:22:53Z","timestamp":1499430173000},"page":"10845-10849","source":"Crossref","is-referenced-by-count":80,"title":["Smart Human\u2010Serum\u2010Albumin\u2013As\n                    <sub>2<\/sub>\n                    O\n                    <sub>3<\/sub>\n                    Nanodrug with Self\u2010Amplified Folate Receptor\u2010Targeting Ability for Chronic Myeloid Leukemia Treatment"],"prefix":"10.1002","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0173-9443","authenticated-orcid":false,"given":"Yongbo","family":"Peng","sequence":"first","affiliation":[{"name":"Molecular Science and Biomedicine Laboratory State Key Laboratory for Chemo\/Bio-Sensing and Chemometrics College of Chemistry and Chemical Engineering College of Life Sciences Aptamer Engineering Center of Hunan Province Hunan University  Changsha 410082 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9910-383X","authenticated-orcid":false,"given":"Zilong","family":"Zhao","sequence":"additional","affiliation":[{"name":"Molecular Science and Biomedicine Laboratory State Key Laboratory for Chemo\/Bio-Sensing and Chemometrics College of Chemistry and Chemical Engineering College of Life Sciences Aptamer Engineering Center of Hunan Province Hunan University  Changsha 410082 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teng","family":"Liu","sequence":"additional","affiliation":[{"name":"Molecular Science and Biomedicine Laboratory State Key Laboratory for Chemo\/Bio-Sensing and Chemometrics College of Chemistry and Chemical Engineering College of Life Sciences Aptamer Engineering Center of Hunan Province Hunan University  Changsha 410082 China"},{"name":"Department of Infectious Diseases Xiangya Hospital Central South University  Changsha 410008 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Xiangya Hospital Central South University  Changsha 410008 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxiao","family":"Hu","sequence":"additional","affiliation":[{"name":"Molecular Science and Biomedicine Laboratory State Key Laboratory for Chemo\/Bio-Sensing and Chemometrics College of Chemistry and Chemical Engineering College of Life Sciences Aptamer Engineering Center of Hunan Province Hunan University  Changsha 410082 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoping","family":"Wei","sequence":"additional","affiliation":[{"name":"Center for Clinical Molecular Medicine Ministry of Education Key Laboratory of Child Development and Dis-orders Children's Hospital of Chongqing Medical University  Chongqing 400014 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4010-0028","authenticated-orcid":false,"given":"Xiaobing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Molecular Science and Biomedicine Laboratory State Key Laboratory for Chemo\/Bio-Sensing and Chemometrics College of Chemistry and Chemical Engineering College of Life Sciences Aptamer Engineering Center of Hunan Province Hunan University  Changsha 410082 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8066-1524","authenticated-orcid":false,"given":"Weihong","family":"Tan","sequence":"additional","affiliation":[{"name":"Molecular Science and Biomedicine Laboratory State Key Laboratory for Chemo\/Bio-Sensing and Chemometrics College of Chemistry and Chemical Engineering College of Life Sciences Aptamer Engineering Center of Hunan Province Hunan University  Changsha 410082 China"},{"name":"Department of Chemistry Department of Physiology and Functional Genomics Center for Research at Bio\/Nano Interface UF Health Cancer Center, UF Genetics Institute and McKnight Brain Institute University of Florida  Gainesville FL 32611-7200 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,8,4]]},"reference":[{"key":"e_1_2_2_1_1","unstructured":"\u00a0"},{"key":"e_1_2_2_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1183424"},{"key":"e_1_2_2_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/joim.12376"},{"key":"e_1_2_2_4_1","first-page":"3893","volume":"62","author":"Miller W. 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