{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T03:50:32Z","timestamp":1792122632811,"version":"4.4.0"},"reference-count":22,"publisher":"Wiley","issue":"26","license":[{"start":{"date-parts":[[2017,5,23]],"date-time":"2017-05-23T00:00:00Z","timestamp":1495497600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Angew Chem Int Ed"],"published-print":{"date-parts":[[2017,6,19]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Systemic amyloidosis is caused by the misfolding of a circulating amyloid precursor protein and the deposition of amyloid fibrils in multiple organs. Chemical and biophysical analysis of amyloid fibrils from human AL and murine AA amyloidosis reveal the same fibril morphologies in different tissues or organs of one patient or diseased animal. The observed structural similarities concerned the fibril morphology, the fibril protein primary and secondary structures, the presence of post\u2010translational modifications and, in case of the AL fibrils, the partially folded characteristics of the polypeptide chain within the fibril. Our data imply for both analyzed forms of amyloidosis that the pathways of protein misfolding are systemically conserved; that is, they follow the same rules irrespective of where inside one body fibrils are formed or accumulated.<\/jats:p>","DOI":"10.1002\/anie.201701761","type":"journal-article","created":{"date-parts":[[2017,5,24]],"date-time":"2017-05-24T01:01:36Z","timestamp":1495587696000},"page":"7510-7514","source":"Crossref","is-referenced-by-count":67,"title":["Common Fibril Structures Imply Systemically Conserved Protein Misfolding Pathways In\u2005Vivo"],"prefix":"10.1002","volume":"56","author":[{"given":"Karthikeyan","family":"Annamalai","sequence":"first","affiliation":[{"name":"Institute of Protein Biochemistry Ulm University  Helmholtzstrasse 8\/1 89081 Ulm Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Falk","family":"Liberta","sequence":"additional","affiliation":[{"name":"Institute of Protein Biochemistry Ulm University  Helmholtzstrasse 8\/1 89081 Ulm Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie\u2010Theres","family":"Vielberg","sequence":"additional","affiliation":[{"name":"Center for Integrated Protein Science Munich (CIPSM) Technische Universit\u00e4t M\u00fcnchen, Department Chemie  85748 Garching Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Close","sequence":"additional","affiliation":[{"name":"Institute of Protein Biochemistry Ulm University  Helmholtzstrasse 8\/1 89081 Ulm Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hauke","family":"Lilie","sequence":"additional","affiliation":[{"name":"Institute for Biochemistry and Biotechnology\/Technical Biochemistry  06120 Halle (Saale) Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl\u2010Heinz","family":"G\u00fchrs","sequence":"additional","affiliation":[{"name":"CF Protemics Leibniz Institute on Aging\u2013, Fritz Lipmann Institute (FLI)  Beutenbergstra\u00dfe 11 07745 Jena Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelika","family":"Schierhorn","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Biochemie und Biotechnologie Serviceeinheit f\u00fcr Massenspektrometrie  06120 Halle (Saale) Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rolf","family":"Koehler","sequence":"additional","affiliation":[{"name":"Institute of Human Genetics  Im Neuenheimer Feld 366 69120 Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Institute of Protein Biochemistry Ulm University  Helmholtzstrasse 8\/1 89081 Ulm Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Haupt","sequence":"additional","affiliation":[{"name":"Institute of Protein Biochemistry Ulm University  Helmholtzstrasse 8\/1 89081 Ulm Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ute","family":"Hegenbart","sequence":"additional","affiliation":[{"name":"Amyloidosis Center Department of Internal Medicine V  Im Neuenheimer Feld 410 69120 Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Sch\u00f6nland","sequence":"additional","affiliation":[{"name":"Amyloidosis Center Department of Internal Medicine V  Im Neuenheimer Feld 410 69120 Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Institute of Protein Biochemistry Ulm University  Helmholtzstrasse 8\/1 89081 Ulm Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Groll","sequence":"additional","affiliation":[{"name":"Center for Integrated Protein Science Munich (CIPSM) Technische Universit\u00e4t M\u00fcnchen, Department Chemie  85748 Garching Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus","family":"F\u00e4ndrich","sequence":"additional","affiliation":[{"name":"Institute of Protein Biochemistry Ulm University  Helmholtzstrasse 8\/1 89081 Ulm Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,5,23]]},"reference":[{"key":"e_1_2_2_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.02.022"},{"key":"e_1_2_2_2_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biochem.75.101304.123901"},{"key":"e_1_2_2_3_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.med.57.121304.131243"},{"key":"e_1_2_2_4_1","doi-asserted-by":"publisher","DOI":"10.3109\/13506129.2014.964858"},{"key":"e_1_2_2_5_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pathol-020712-163913"},{"key":"e_1_2_2_6_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-biochem-072611-130030"},{"key":"e_1_2_2_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/385787a0"},{"key":"e_1_2_2_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/78980"},{"key":"e_1_2_2_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2010.11.028"},{"key":"e_1_2_2_10_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M304473200"},{"key":"e_1_2_2_11_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1317488111"},{"key":"e_1_2_2_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201511524"},{"key":"e_1_2_2_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201511524"},{"key":"e_1_2_2_13_1","first-page":"1339","volume":"148","author":"Schiffer M.","year":"1996","journal-title":"Am. J. Pathol."},{"key":"e_1_2_2_14_1","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.2001.4863"},{"key":"e_1_2_2_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2008.11.005"},{"key":"e_1_2_2_16_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1138718"},{"key":"e_1_2_2_17_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.092205999"},{"key":"e_1_2_2_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.2607"},{"key":"e_1_2_2_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.2411"},{"key":"e_1_2_2_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2007.08.068"},{"key":"e_1_2_2_21_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1141448"}],"container-title":["Angewandte Chemie International Edition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fanie.201701761","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anie.201701761","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T23:52:32Z","timestamp":1694303552000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/anie.201701761"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5,23]]},"references-count":22,"journal-issue":{"issue":"26","published-print":{"date-parts":[[2017,6,19]]}},"alternative-id":["10.1002\/anie.201701761"],"URL":"https:\/\/doi.org\/10.1002\/anie.201701761","archive":["Portico"],"relation":{},"ISSN":["1433-7851","1521-3773"],"issn-type":[{"value":"1433-7851","type":"print"},{"value":"1521-3773","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,5,23]]}}}