{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T20:12:00Z","timestamp":1779394320352,"version":"3.53.1"},"reference-count":79,"publisher":"Wiley","issue":"24","license":[{"start":{"date-parts":[[2017,5,4]],"date-time":"2017-05-04T00:00:00Z","timestamp":1493856000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["25221301"],"award-info":[{"award-number":["25221301"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["16H01141"],"award-info":[{"award-number":["16H01141"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Angew Chem Int Ed"],"published-print":{"date-parts":[[2017,6,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Aurachins\u2005A and B are alkaloids having 3\u2010hydroxyquinoline N\u2010oxide cores. An efficient method for the synthesis of 3\u2010hydroxyquinoline N\u2010oxides was established and is amenable to the total syntheses of aurachins\u2005A and B. Alkylation of 1\u2010(2\u2010nitrophenyl)butan\u20102\u2010one with farnesyl bromide took place selectively at the benzylic position, and subsequent treatment of the alkylated product with sodium tert\u2010butoxide in dimethyl sulfoxide gave aurachin\u2005B. Alkylation of 1\u2010(2\u2010nitrophenyl)butan\u20102\u2010one with an epoxy iodide derived from farnesol was used to access aurachin\u2005A.<\/jats:p>","DOI":"10.1002\/anie.201702204","type":"journal-article","created":{"date-parts":[[2017,5,4]],"date-time":"2017-05-04T11:13:43Z","timestamp":1493896423000},"page":"6980-6983","source":"Crossref","is-referenced-by-count":14,"title":["Total Syntheses of Aurachins\u2005A and B"],"prefix":"10.1002","volume":"56","author":[{"given":"Haruhiko","family":"Hattori","sequence":"first","affiliation":[{"name":"Graduate School of Pharmaceutical Sciences Nagoya University, Furo-cho, Chikusa-ku  Nagoya 464-8601 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4036-0062","authenticated-orcid":false,"given":"Satoshi","family":"Yokoshima","sequence":"additional","affiliation":[{"name":"Graduate School of Pharmaceutical Sciences Nagoya University, Furo-cho, Chikusa-ku  Nagoya 464-8601 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tohru","family":"Fukuyama","sequence":"additional","affiliation":[{"name":"Graduate School of Pharmaceutical Sciences Nagoya University, Furo-cho, Chikusa-ku  Nagoya 464-8601 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,5,4]]},"reference":[{"key":"e_1_2_2_1_1","doi-asserted-by":"publisher","DOI":"10.7164\/antibiotics.40.258"},{"key":"e_1_2_2_2_1","unstructured":"Isolation of aurachins E-L fromStigmatella aurantiacaSg a15:"},{"key":"e_1_2_2_3_2","doi-asserted-by":"publisher","DOI":"10.1021\/np8003084"},{"key":"e_1_2_2_4_2","doi-asserted-by":"publisher","DOI":"10.1021\/np800325z"},{"key":"e_1_2_2_5_1","unstructured":"Isolation of aurachin RE fromRhodococcus erythropolisJCM 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