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However, coexisting structurally similar isomers often render an unambiguous identification impossible. Other powerful techniques such as gas\u2010phase infrared (IR) spectroscopy have been limited to smaller glycans, since conformational flexibility and thermal activation during the measurement result in poor spectral resolution. This limitation can be overcome by using cold\u2010ion spectroscopy. The vibrational fingerprints of cold oligosaccharide ions exhibit a wealth of well\u2010resolved absorption features that are diagnostic for minute structural variations. The unprecedented resolution of cold\u2010ion spectroscopy coupled with tandem MS may render this the key technology to unravel complex glycomes.<\/jats:p>","DOI":"10.1002\/anie.201702896","type":"journal-article","created":{"date-parts":[[2017,5,17]],"date-time":"2017-05-17T11:46:38Z","timestamp":1495021598000},"page":"11248-11251","source":"Crossref","is-referenced-by-count":143,"title":["Glycan Fingerprinting via Cold\u2010Ion Infrared Spectroscopy"],"prefix":"10.1002","volume":"56","author":[{"given":"Eike","family":"Mucha","sequence":"first","affiliation":[{"name":"Fritz-Haber-Institut der Max-Planck-Gesellschaft  Faradayweg 4\u20136 14195 Berlin Germany"},{"name":"Institut f\u00fcr Chemie und Biochemie der Freien Universit\u00e4t Berlin  Takustra\u00dfe 3 14195 Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Isabel","family":"Gonz\u00e1lez\u2005Fl\u00f3rez","sequence":"additional","affiliation":[{"name":"Fritz-Haber-Institut der Max-Planck-Gesellschaft  Faradayweg 4\u20136 14195 Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mateusz","family":"Marianski","sequence":"additional","affiliation":[{"name":"Fritz-Haber-Institut der Max-Planck-Gesellschaft  Faradayweg 4\u20136 14195 Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel A.","family":"Thomas","sequence":"additional","affiliation":[{"name":"Fritz-Haber-Institut der Max-Planck-Gesellschaft  Faradayweg 4\u20136 14195 Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Waldemar","family":"Hoffmann","sequence":"additional","affiliation":[{"name":"Fritz-Haber-Institut der Max-Planck-Gesellschaft  Faradayweg 4\u20136 14195 Berlin Germany"},{"name":"Institut f\u00fcr Chemie und Biochemie der Freien Universit\u00e4t Berlin  Takustra\u00dfe 3 14195 Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weston B.","family":"Struwe","sequence":"additional","affiliation":[{"name":"Oxford Glycobiology Institute Department of Biochemistry University of Oxford  Oxford OX1 3QU UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heung S.","family":"Hahm","sequence":"additional","affiliation":[{"name":"Max-Planck-Institut f\u00fcr Kolloid- und Grenzfl\u00e4chenforschung  Am M\u00fchlenberg 1 14476 Potsdam Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandy","family":"Gewinner","sequence":"additional","affiliation":[{"name":"Fritz-Haber-Institut der Max-Planck-Gesellschaft  Faradayweg 4\u20136 14195 Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wieland","family":"Sch\u00f6llkopf","sequence":"additional","affiliation":[{"name":"Fritz-Haber-Institut der Max-Planck-Gesellschaft  Faradayweg 4\u20136 14195 Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3394-8466","authenticated-orcid":false,"given":"Peter H.","family":"Seeberger","sequence":"additional","affiliation":[{"name":"Max-Planck-Institut f\u00fcr Kolloid- und Grenzfl\u00e4chenforschung  Am M\u00fchlenberg 1 14476 Potsdam Germany"},{"name":"Institut f\u00fcr Chemie und Biochemie der Freien Universit\u00e4t Berlin  Arnimallee 22 14195 Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7611-8740","authenticated-orcid":false,"given":"Gert","family":"von\u2005Helden","sequence":"additional","affiliation":[{"name":"Fritz-Haber-Institut der Max-Planck-Gesellschaft  Faradayweg 4\u20136 14195 Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8054-4718","authenticated-orcid":false,"given":"Kevin","family":"Pagel","sequence":"additional","affiliation":[{"name":"Fritz-Haber-Institut der Max-Planck-Gesellschaft  Faradayweg 4\u20136 14195 Berlin Germany"},{"name":"Institut f\u00fcr Chemie und Biochemie der Freien Universit\u00e4t Berlin  Takustra\u00dfe 3 14195 Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,6,8]]},"reference":[{"key":"e_1_2_2_1_1","unstructured":"\u00a0"},{"key":"e_1_2_2_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/glycob\/3.2.97"},{"key":"e_1_2_2_3_2","doi-asserted-by":"publisher","DOI":"10.1021\/cr940283b"},{"key":"e_1_2_2_4_1","unstructured":"\u00a0"},{"key":"e_1_2_2_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.437"},{"key":"e_1_2_2_6_2","doi-asserted-by":"crossref","unstructured":"L. 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