{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T00:05:09Z","timestamp":1788393909337,"version":"build-2803163510"},"reference-count":36,"publisher":"Wiley","issue":"40","license":[{"start":{"date-parts":[[2017,8,29]],"date-time":"2017-08-29T00:00:00Z","timestamp":1503964800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2017,8,29]],"date-time":"2017-08-29T00:00:00Z","timestamp":1503964800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"name":"German Federal Ministry of Education and Research (BMBF)","award":["031A184A"],"award-info":[{"award-number":["031A184A"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Angew Chem Int Ed"],"published-print":{"date-parts":[[2017,9,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    A cyanide\u2010free platform technology for the synthesis of chiral nitriles by biocatalytic enantioselective dehydration of a wide range of aldoximes is reported. The nitriles were obtained with high enantiomeric excess of &gt;90\u2009%\n                    <jats:italic>ee<\/jats:italic>\n                    (and up to 99\u2009%\n                    <jats:italic>ee<\/jats:italic>\n                    ) in many cases, and a \u201cprivileged substrate structure\u201d with respect to high enantioselectivity was identified. Furthermore, a surprising phenomenon was observed for the enantiospecificity that is usually not observed in enzyme catalysis. Depending on whether the\n                    <jats:italic>E<\/jats:italic>\n                    or\n                    <jats:italic>Z<\/jats:italic>\n                    \u2005isomer of the racemic aldoxime substrate was employed, one or the other enantiomer of the corresponding nitrile was formed preferentially with the same enzyme.\n                  <\/jats:p>","DOI":"10.1002\/anie.201702952","type":"journal-article","created":{"date-parts":[[2017,7,3]],"date-time":"2017-07-03T11:17:00Z","timestamp":1499080620000},"page":"12361-12366","source":"Crossref","is-referenced-by-count":75,"title":["Cyanide\u2010Free and Broadly Applicable Enantioselective Synthetic Platform for Chiral Nitriles through a Biocatalytic Approach"],"prefix":"10.1002","volume":"56","author":[{"given":"Tobias","family":"Betke","sequence":"first","affiliation":[{"name":"Chair of Organic Chemistry I, Faculty of Chemistry Bielefeld University  Universit\u00e4tsstrasse 25 33615 Bielefeld Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"Rommelmann","sequence":"additional","affiliation":[{"name":"Chair of Organic Chemistry I, Faculty of Chemistry Bielefeld University  Universit\u00e4tsstrasse 25 33615 Bielefeld Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiko","family":"Oike","sequence":"additional","affiliation":[{"name":"Chair of Organic Chemistry I, Faculty of Chemistry Bielefeld University  Universit\u00e4tsstrasse 25 33615 Bielefeld Germany"},{"name":"Biotechnology Research Center Toyama Prefectural University  5180 Kurokawa Imizu Toyama 939-0398 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhisa","family":"Asano","sequence":"additional","affiliation":[{"name":"Biotechnology Research Center Toyama Prefectural University  5180 Kurokawa Imizu Toyama 939-0398 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8582-2107","authenticated-orcid":false,"given":"Harald","family":"Gr\u00f6ger","sequence":"additional","affiliation":[{"name":"Chair of Organic Chemistry I, Faculty of Chemistry Bielefeld University  Universit\u00e4tsstrasse 25 33615 Bielefeld Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,8,29]]},"reference":[{"key":"e_1_2_2_1_1","unstructured":"\u00a0"},{"key":"e_1_2_2_2_2","volume-title":"Pharmaceutical Substances: Syntheses, Patents, Applications","author":"Kleemann A.","year":"2001"},{"key":"e_1_2_2_3_2","volume-title":"Science of Synthesis, Vol.\u200519 of Three Carbon-Heteroatom Bonds: Nitriles, Isocyanides, and Derivatives","year":"2004"},{"key":"e_1_2_2_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm100762r"},{"key":"e_1_2_2_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/op900226j"},{"key":"e_1_2_2_6_1","unstructured":"\u00a0"},{"key":"e_1_2_2_7_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm030091l"},{"key":"e_1_2_2_8_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.oprd.5b00058"},{"key":"e_1_2_2_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr020038p"},{"key":"e_1_2_2_10_1","first-page":"267","volume-title":"Comprehensive Asymmetric Catalysis, Vol.\u20051","author":"RajanBabu T. 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