{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T15:56:40Z","timestamp":1782921400907,"version":"3.54.5"},"reference-count":47,"publisher":"Wiley","issue":"30","license":[{"start":{"date-parts":[[2017,6,14]],"date-time":"2017-06-14T00:00:00Z","timestamp":1497398400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"MOST","award":["106-2912-I-005 -501(International Collaborations - Concurrent)"],"award-info":[{"award-number":["106-2912-I-005 -501(International Collaborations - Concurrent)"]}]},{"name":"MOST","award":["103-2113-M-005 -007 -MY3"],"award-info":[{"award-number":["103-2113-M-005 -007 -MY3"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Angew Chem Int Ed"],"published-print":{"date-parts":[[2017,7,17]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Small\u2010molecule compounds targeting trinucleotide repeats in DNA have considerable potential as therapeutic or diagnostic agents against many neurological diseases. Ni<jats:sup>II<\/jats:sup>(Chro)<jats:sub>2<\/jats:sub> (Chro=chromomycin A3) binds specifically to the minor groove of (CCG)<jats:sub><jats:italic>n<\/jats:italic><\/jats:sub> repeats in duplex DNA, with unique fluorescence features that may serve as a probe for disease detection. Crystallographic studies revealed that the specificity originates from the large\u2010scale spatial rearrangement of the DNA structure, including extrusion of consecutive bases and backbone distortions, with a sharp bending of the duplex accompanied by conformational changes in the Ni<jats:sup>II<\/jats:sup> chelate itself. The DNA deformation of CCG repeats upon binding forms a GGCC tetranucleotide tract, which is recognized by Ni<jats:sup>II<\/jats:sup>(Chro)<jats:sub>2<\/jats:sub>. The extruded cytosine and last guanine nucleotides form water\u2010mediated hydrogen bonds, which aid in ligand recognition. The recognition can be accounted for by the classic induced\u2010fit paradigm.<\/jats:p>","DOI":"10.1002\/anie.201703989","type":"journal-article","created":{"date-parts":[[2017,5,24]],"date-time":"2017-05-24T00:40:12Z","timestamp":1495586412000},"page":"8761-8765","source":"Crossref","is-referenced-by-count":32,"title":["Induced\u2010Fit Recognition of CCG Trinucleotide Repeats by a Nickel\u2013Chromomycin Complex Resulting in Large\u2010Scale DNA Deformation"],"prefix":"10.1002","volume":"56","author":[{"given":"Wen\u2010Hsuan","family":"Tseng","sequence":"first","affiliation":[{"name":"Institute of Genomics and Bioinformatics National Chung Hsing University  250 Kuo-kuang Rd. Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chung\u2010ke","family":"Chang","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Sciences Academia Sinica  128 Sec. 2, Academia Rd. Nankang Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei\u2010Ching","family":"Wu","sequence":"additional","affiliation":[{"name":"Institute of Genomics and Bioinformatics National Chung Hsing University  250 Kuo-kuang Rd. Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nien\u2010Jen","family":"Hu","sequence":"additional","affiliation":[{"name":"Institute of Biochemistry National Chung Hsing University  250 Kuo-kuang Rd. Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gene\u2010Hsiang","family":"Lee","sequence":"additional","affiliation":[{"name":"Instrumentation Center College of Science National Taiwan University  No.1, Sec. 4, Roosevelt Rd. Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ching\u2010Cherng","family":"Tzeng","sequence":"additional","affiliation":[{"name":"Department of Pathology Chi Mei Medical Center  No.901, Zhonghua Rd. Tainan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Neidle","sequence":"additional","affiliation":[{"name":"The School of Pharmacy University College London  London WC1N 1AX UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming\u2010Hon","family":"Hou","sequence":"additional","affiliation":[{"name":"Institute of Genomics and Bioinformatics National Chung Hsing University  250 Kuo-kuang Rd. Taichung Taiwan"},{"name":"Institute of Biotechnology National Chung Hsing University  250 Kuo-kuang Rd. Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,6,14]]},"reference":[{"key":"e_1_2_2_1_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.29.051605.113042"},{"key":"e_1_2_2_2_1","unstructured":"\u00a0"},{"key":"e_1_2_2_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature05977"},{"key":"e_1_2_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6603(00)66029-4"},{"key":"e_1_2_2_5_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-biochem-060614-034010"},{"key":"e_1_2_2_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201405637"},{"key":"e_1_2_2_6_3","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201405637"},{"key":"e_1_2_2_7_1","unstructured":"\u00a0"},{"key":"e_1_2_2_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkt084"},{"key":"e_1_2_2_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio708"},{"key":"e_1_2_2_10_1","unstructured":"\u00a0"},{"key":"e_1_2_2_11_2","doi-asserted-by":"publisher","DOI":"10.2174\/1568026615666150413155030"},{"key":"e_1_2_2_12_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja9020149"},{"key":"e_1_2_2_13_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0901824106"},{"key":"e_1_2_2_14_1","unstructured":"\u00a0"},{"key":"e_1_2_2_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/cbic.201600200"},{"key":"e_1_2_2_16_2","first-page":"7090","volume":"44","author":"Mukherjee S.","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"e_1_2_2_17_1","unstructured":"\u00a0"},{"key":"e_1_2_2_18_2","first-page":"444","volume":"21","author":"Ikeda T.","year":"1991","journal-title":"Jpn. J. Clin. Oncol."},{"key":"e_1_2_2_19_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0004626"},{"key":"e_1_2_2_20_1","unstructured":"\u00a0"},{"key":"e_1_2_2_21_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0043792"},{"key":"e_1_2_2_22_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkh549"},{"key":"e_1_2_2_23_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi701915f"},{"key":"e_1_2_2_24_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi00126a021"},{"key":"e_1_2_2_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkp358"},{"key":"e_1_2_2_26_1","unstructured":"\u00a0"},{"key":"e_1_2_2_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.sbi.2012.05.006"},{"key":"e_1_2_2_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.232"},{"key":"e_1_2_2_29_1","doi-asserted-by":"publisher","DOI":"10.1021\/jo001372t"},{"key":"e_1_2_2_30_1","unstructured":"\u00a0"},{"key":"e_1_2_2_31_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja0600936"},{"key":"e_1_2_2_32_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/29.3.693"},{"key":"e_1_2_2_33_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2434016100"},{"key":"e_1_2_2_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkg237"},{"key":"e_1_2_2_35_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi060304j"},{"key":"e_1_2_2_36_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1703066114"},{"key":"e_1_2_2_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchem.1375"},{"key":"e_1_2_2_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201308070"},{"key":"e_1_2_2_38_2","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201308070"},{"key":"e_1_2_2_39_1","unstructured":"\u00a0"},{"key":"e_1_2_2_40_2","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.1996.0643"},{"key":"e_1_2_2_41_2","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.1997.1453"},{"key":"e_1_2_2_42_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gks557"},{"key":"e_1_2_2_43_1","doi-asserted-by":"publisher","DOI":"10.2353\/jmoldx.2008.070073"},{"key":"e_1_2_2_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2006.73"},{"key":"e_1_2_2_45_1","doi-asserted-by":"publisher","DOI":"10.1039\/c1cc11370d"}],"container-title":["Angewandte Chemie International Edition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fanie.201703989","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anie.201703989","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,16]],"date-time":"2023-09-16T07:38:10Z","timestamp":1694849890000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/anie.201703989"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,14]]},"references-count":47,"journal-issue":{"issue":"30","published-print":{"date-parts":[[2017,7,17]]}},"alternative-id":["10.1002\/anie.201703989"],"URL":"https:\/\/doi.org\/10.1002\/anie.201703989","archive":["Portico"],"relation":{},"ISSN":["1433-7851","1521-3773"],"issn-type":[{"value":"1433-7851","type":"print"},{"value":"1521-3773","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6,14]]}}}