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Under near physiological conditions, the persulfide prodrug can be activated by an esterase to generate a \u201chydroxymethyl persulfide\u201d intermediate, which rapidly collapses to form a defined persulfide. Such persulfide prodrugs can be used either as chemical tools to study persulfide chemistry and biology or for future development as H\n                    <jats:sub>2<\/jats:sub>\n                    S\u2010based therapeutic reagents. Using the persulfide prodrugs developed in this study, the reactivity between\n                    <jats:italic>S<\/jats:italic>\n                    \u2010methyl methanethiosulfonate (MMTS) with persulfide was unambiguously demonstrated. Furthermore, a representative prodrug exhibited potent cardioprotective effects in a murine model of myocardial ischemia\u2010reperfusion (MI\/R) injury with a bell shape therapeutic profile.\n                  <\/jats:p>","DOI":"10.1002\/anie.201704117","type":"journal-article","created":{"date-parts":[[2017,7,12]],"date-time":"2017-07-12T12:42:41Z","timestamp":1499863361000},"page":"11749-11753","source":"Crossref","is-referenced-by-count":100,"title":["An Esterase\u2010Sensitive Prodrug Approach for Controllable Delivery of Persulfide Species"],"prefix":"10.1002","volume":"56","author":[{"given":"Yueqin","family":"Zheng","sequence":"first","affiliation":[{"name":"Department of Chemistry Georgia State University  Atlanta GA 30303-3083 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingchen","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Chemistry Georgia State University  Atlanta GA 30303-3083 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Li","sequence":"additional","affiliation":[{"name":"Cardiovascular Center of Excellence Louisiana State University Health Sciences Center  New Orleans LA 70112 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengnan","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Chemistry Georgia State University  Atlanta GA 30303-3083 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chelsea L.","family":"Organ","sequence":"additional","affiliation":[{"name":"Cardiovascular Center of Excellence Louisiana State University Health Sciences Center  New Orleans LA 70112 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rishi K.","family":"Trivedi","sequence":"additional","affiliation":[{"name":"Cardiovascular Center of Excellence Louisiana State University Health Sciences Center  New Orleans LA 70112 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siming","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Chemistry Georgia State University  Atlanta GA 30303-3083 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Lefer","sequence":"additional","affiliation":[{"name":"Cardiovascular Center of Excellence Louisiana State University Health Sciences Center  New Orleans LA 70112 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binghe","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Chemistry Georgia State University  Atlanta GA 30303-3083 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,8,16]]},"reference":[{"key":"e_1_2_2_1_1","unstructured":"\u00a0"},{"key":"e_1_2_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2015.06.004"},{"key":"e_1_2_2_3_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00017.2011"},{"key":"e_1_2_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2014.09.007"},{"key":"e_1_2_2_5_2","doi-asserted-by":"publisher","DOI":"10.1586\/ecp.10.134"},{"key":"e_1_2_2_6_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.6b03780"},{"key":"e_1_2_2_7_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.6b01373"},{"key":"e_1_2_2_8_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1321232111"},{"key":"e_1_2_2_9_2","doi-asserted-by":"publisher","DOI":"10.1039\/C6CS00585C"},{"key":"e_1_2_2_10_1","unstructured":"\u00a0"},{"key":"e_1_2_2_11_2","doi-asserted-by":"publisher","DOI":"10.3945\/jn.114.208066"},{"key":"e_1_2_2_12_2","doi-asserted-by":"publisher","DOI":"10.3390\/antiox5040046"},{"key":"e_1_2_2_13_1","unstructured":"\u00a0"},{"key":"e_1_2_2_14_2","doi-asserted-by":"publisher","DOI":"10.1021\/cb400090d"},{"key":"e_1_2_2_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.753467"},{"key":"e_1_2_2_16_2","unstructured":"Y. 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