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We designed two small hybrid molecules (<jats:bold>1<\/jats:bold> and <jats:bold>2<\/jats:bold>) by linking a ligand for ubiquitin ligase (cellular inhibitor of apoptosis protein 1; cIAP1) with probes for mHtt aggregates, anticipating that these compounds would recruit cIAP1 to mHtt and induce selective degradation by the ubiquitin\u2010proteasome system. 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