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Herein, novel glucose oxidase (GOD)\u2010loaded therapeutic vesicular NRs (<jats:italic>thera<\/jats:italic>NR) are constructed based on a diblock copolymer containing poly(ethylene glycol) (PEG) and copolymerized phenylboronic ester or piperidine\u2010functionalized methacrylate (P(PBEM\u2010<jats:italic>co<\/jats:italic>\u2010PEM)). Upon systemic injection, <jats:italic>thera<\/jats:italic>NR are inactive in normal tissues. At a tumor site, <jats:italic>thera<\/jats:italic>NR are specifically activated by the tumor acidity via improved permeability of the membranes. Hydrogen peroxide (H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub>) production by the catalysis of GOD in <jats:italic>thera<\/jats:italic>NR increases tumor oxidative stress significantly. Meanwhile, high levels of H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub> induce self\u2010destruction of <jats:italic>thera<\/jats:italic>NR releasing quinone methide (QM) to deplete glutathione and suppress the antioxidant ability of cancer cells. Finally, <jats:italic>thera<\/jats:italic>NR efficiently kill cancer cells and ablate tumors via the synergistic effect.<\/jats:p>","DOI":"10.1002\/anie.201706964","type":"journal-article","created":{"date-parts":[[2017,9,20]],"date-time":"2017-09-20T12:24:23Z","timestamp":1505910263000},"page":"14025-14030","source":"Crossref","is-referenced-by-count":191,"title":["Therapeutic Vesicular Nanoreactors with Tumor\u2010Specific Activation and Self\u2010Destruction for Synergistic Tumor Ablation"],"prefix":"10.1002","volume":"56","author":[{"given":"Junjie","family":"Li","sequence":"first","affiliation":[{"name":"CAS Key Laboratory of Soft Matter Chemistry Department of Polymer Science and Engineering University of Science and Technology of China  Hefei Anhui 230026 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anjaneyulu","family":"Dirisala","sequence":"additional","affiliation":[{"name":"Innovation Center of Nanomedicine Kawasaki Institute of Industrial Promotion 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