{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T14:34:44Z","timestamp":1789655684488,"version":"4.0.1"},"reference-count":45,"publisher":"Wiley","issue":"42","license":[{"start":{"date-parts":[[2017,9,11]],"date-time":"2017-09-11T00:00:00Z","timestamp":1505088000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100004334","name":"Merck","doi-asserted-by":"publisher","award":["LKR#144525"],"award-info":[{"award-number":["LKR#144525"]}],"id":[{"id":"10.13039\/100004334","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Angew Chem Int Ed"],"published-print":{"date-parts":[[2017,10,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Systemic fungal infections represent an important public health concern, and new antifungal agents are highly desirable. Herein, we describe the design, synthesis, and biological evaluation of a novel class of antifungal compounds called antibody\u2010recruiting molecules targeting fungi (ARM\u2010Fs). Our approach relies on the use of non\u2010peptidic small molecules, which selectively bind fungal cells and recruit endogenous antibodies to their surfaces, resulting in immune\u2010mediated clearance. Using the opportunistic fungal pathogen Candida albicans as a model, we identified a highly specific bifunctional molecule able to mediate the engulfment and phagocytosis of C. albicans cells by human immune cells in biologically relevant functional assays. This work represents a novel therapeutic approach to treating fungal illness with significant potential to complement and\/or combine with existing treatment strategies.<\/jats:p>","DOI":"10.1002\/anie.201707536","type":"journal-article","created":{"date-parts":[[2017,8,9]],"date-time":"2017-08-09T14:22:40Z","timestamp":1502288560000},"page":"13036-13040","source":"Crossref","is-referenced-by-count":18,"title":["Neutralization of Pathogenic Fungi with Small\u2010Molecule Immunotherapeutics"],"prefix":"10.1002","volume":"56","author":[{"given":"Egor","family":"Chirkin","sequence":"first","affiliation":[{"name":"Department of Chemistry Yale University  225 Prospect Street New Haven CT 06511 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viswanathan","family":"Muthusamy","sequence":"additional","affiliation":[{"name":"Department of Chemistry Yale University  225 Prospect Street New Haven CT 06511 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Mann","sequence":"additional","affiliation":[{"name":"Merck &amp; Co., Inc.  2000 Galloping Hill Road Kenilworth NJ 07033 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terry","family":"Roemer","sequence":"additional","affiliation":[{"name":"Prokaryotics, Inc.  1000 Morris Ave, STEM Bldg., Suite 5\u201313 Union NJ 07083 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe G.","family":"Nantermet","sequence":"additional","affiliation":[{"name":"Merck &amp; Co., Inc.  2000 Galloping Hill Road Kenilworth NJ 07033 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1102-8012","authenticated-orcid":false,"given":"David A.","family":"Spiegel","sequence":"additional","affiliation":[{"name":"Department of Chemistry Yale University  225 Prospect Street New Haven CT 06511 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,9,11]]},"reference":[{"key":"e_1_2_2_1_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3004404"},{"key":"e_1_2_2_2_1","unstructured":"\u00a0"},{"key":"e_1_2_2_3_2","first-page":"175","volume":"3","author":"Kriengkauykiat J.","year":"2001","journal-title":"Clin. 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