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Here, we report noninvasive X\u2010ray imaging of renal clearable gold NPs (AuNPs) in normal and nephropathic kidneys. By quantifying the transport kinetics of the AuNPs in cortex, medulla and pelvis of the normal and injured kidneys, we found that ureteral obstruction not just blocked the NP elimination through the ureter but also slowed down their transport from the medulla to pelvis and enhanced the cellular uptake. Moreover, the transport kinetics of the NPs and renal anatomic details can be precisely correlated with local pathological lesion. These findings not only advance our understandings of the nano\u2010bio interactions in kidneys but also offer a new pathway to noninvasively image kidney dysfunction and local injuries at the anatomical level.<\/jats:p>","DOI":"10.1002\/anie.201707819","type":"journal-article","created":{"date-parts":[[2017,9,7]],"date-time":"2017-09-07T19:52:00Z","timestamp":1504813920000},"page":"13356-13360","source":"Crossref","is-referenced-by-count":101,"title":["In\u2005Vivo X\u2010ray Imaging of Transport of Renal Clearable Gold Nanoparticles in the Kidneys"],"prefix":"10.1002","volume":"56","author":[{"given":"Jing","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Chemistry and Biochemistry The University of Texas at Dallas  800 W. Campbell Rd. 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