{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T21:01:36Z","timestamp":1791493296579,"version":"4.3.4"},"reference-count":40,"publisher":"Wiley","issue":"44","license":[{"start":{"date-parts":[[2017,9,22]],"date-time":"2017-09-22T00:00:00Z","timestamp":1506038400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Angew Chem Int Ed"],"published-print":{"date-parts":[[2017,10,23]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Photodynamic therapy (PDT) has emerged as an important minimally invasive tumor treatment technology. The search for an effective photosensitizer to realize selective cancer treatment has become one of the major foci in recent developments of PDT technology. Controllable singlet\u2010oxygen release based on specific cancer\u2010associated events, as another major layer of selectivity mode, has attracted great attention in recent years. Here, for the first time, we demonstrated that a novel mixed\u2010metal metal\u2013organic framework nanoparticle (MOF NP) photosensitizer can be activated by a hydrogen sulfide (H<jats:sub>2<\/jats:sub>S) signaling molecule in a specific tumor microenvironment for PDT against cancer with controllable singlet\u2010oxygen release in living cells. The effective removal of tumors in\u2005vivo further confirmed the satisfactory treatment effect of the MOF NP photosensitizer.<\/jats:p>","DOI":"10.1002\/anie.201708005","type":"journal-article","created":{"date-parts":[[2017,8,31]],"date-time":"2017-08-31T08:52:12Z","timestamp":1504169532000},"page":"13752-13756","source":"Crossref","is-referenced-by-count":342,"title":["H<sub>2<\/sub>S\u2010Activable MOF Nanoparticle Photosensitizer for Effective Photodynamic Therapy against Cancer with Controllable Singlet\u2010Oxygen Release"],"prefix":"10.1002","volume":"56","author":[{"given":"Yu","family":"Ma","sequence":"first","affiliation":[{"name":"College of Chemistry, Chemical Engineering and Materials Science Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong Key Laboratory of Molecular and Nano Probes Ministry of Education Institute of Molecular and Nano Science Shandong Normal University  Jinan 250014 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangyuan","family":"Li","sequence":"additional","affiliation":[{"name":"College of Chemistry, Chemical Engineering and Materials Science Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong Key Laboratory of Molecular and Nano Probes Ministry of Education Institute of Molecular and Nano Science Shandong Normal University  Jinan 250014 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aijie","family":"Li","sequence":"additional","affiliation":[{"name":"College of Chemistry, Chemical Engineering and Materials Science Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong Key Laboratory of Molecular and Nano Probes Ministry of Education Institute of Molecular and Nano Science Shandong Normal University  Jinan 250014 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Yang","sequence":"additional","affiliation":[{"name":"College of Chemistry, Chemical Engineering and Materials Science Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong Key Laboratory of Molecular and Nano Probes Ministry of Education Institute of Molecular and Nano Science Shandong Normal University  Jinan 250014 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caiyun","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Chemistry, Chemical Engineering and Materials Science Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong Key Laboratory of Molecular and Nano Probes Ministry of Education Institute of Molecular and Nano Science Shandong Normal University  Jinan 250014 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8712-7025","authenticated-orcid":false,"given":"Bo","family":"Tang","sequence":"additional","affiliation":[{"name":"College of Chemistry, Chemical Engineering and Materials Science Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong Key Laboratory of Molecular and Nano Probes Ministry of Education Institute of Molecular and Nano Science Shandong Normal University  Jinan 250014 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,9,22]]},"reference":[{"key":"e_1_2_2_1_1","unstructured":"\u00a0"},{"key":"e_1_2_2_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1071"},{"key":"e_1_2_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2008.08.003"},{"key":"e_1_2_2_4_2","doi-asserted-by":"publisher","DOI":"10.1021\/cr400532z"},{"key":"e_1_2_2_5_1","unstructured":"\u00a0"},{"key":"e_1_2_2_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd1984"},{"key":"e_1_2_2_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3297"},{"key":"e_1_2_2_8_1","unstructured":"\u00a0"},{"key":"e_1_2_2_9_2","doi-asserted-by":"publisher","DOI":"10.1039\/B915149B"},{"key":"e_1_2_2_10_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja801631c"},{"key":"e_1_2_2_11_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.5b04501"},{"key":"e_1_2_2_12_1","unstructured":"\u00a0"},{"key":"e_1_2_2_13_2","doi-asserted-by":"publisher","DOI":"10.3390\/ma6030817"},{"key":"e_1_2_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pdpdt.2010.02.001"},{"key":"e_1_2_2_15_2","doi-asserted-by":"publisher","DOI":"10.1021\/cr900236h"},{"key":"e_1_2_2_16_1","unstructured":"\u00a0"},{"key":"e_1_2_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2012.09.012"},{"key":"e_1_2_2_18_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-med-040210-162544"},{"key":"e_1_2_2_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2015.08.008"},{"key":"e_1_2_2_20_1","unstructured":"\u00a0"},{"key":"e_1_2_2_21_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.6b00007"},{"key":"e_1_2_2_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201602417"},{"key":"e_1_2_2_22_3","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201602417"},{"key":"e_1_2_2_23_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja508679h"},{"key":"e_1_2_2_24_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5b04069"},{"key":"e_1_2_2_25_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.6b06663"},{"key":"e_1_2_2_26_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1306241110"},{"key":"e_1_2_2_27_1","first-page":"276109","author":"Josefsen L. B.","year":"2008","journal-title":"Met.-Based Drugs"},{"key":"e_1_2_2_28_1","unstructured":"\u00a0"},{"key":"e_1_2_2_29_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja207851s"},{"key":"e_1_2_2_30_2","doi-asserted-by":"publisher","DOI":"10.1021\/ac503622n"},{"key":"e_1_2_2_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.snb.2016.11.085"},{"key":"e_1_2_2_32_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.6b12118"},{"key":"e_1_2_2_33_1","doi-asserted-by":"publisher","DOI":"10.1039\/c0dt01401j"},{"key":"e_1_2_2_34_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja307953m"},{"key":"e_1_2_2_35_1","doi-asserted-by":"publisher","DOI":"10.1021\/la902235d"},{"key":"e_1_2_2_36_1","unstructured":"\u00a0"},{"key":"e_1_2_2_37_2","doi-asserted-by":"publisher","DOI":"10.1021\/nl052396o"},{"key":"e_1_2_2_38_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201203767"},{"key":"e_1_2_2_38_3","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201203767"}],"container-title":["Angewandte Chemie International Edition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fanie.201708005","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anie.201708005","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T14:57:20Z","timestamp":1696604240000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/anie.201708005"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9,22]]},"references-count":40,"journal-issue":{"issue":"44","published-print":{"date-parts":[[2017,10,23]]}},"alternative-id":["10.1002\/anie.201708005"],"URL":"https:\/\/doi.org\/10.1002\/anie.201708005","archive":["Portico"],"relation":{},"ISSN":["1433-7851","1521-3773"],"issn-type":[{"value":"1433-7851","type":"print"},{"value":"1521-3773","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,9,22]]}}}