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In order to circumvent the handling, storage, and transportation of elemental bromine, a continuous bromine generator using bromate\u2013bromide synproportionation can optionally be attached upstream. Monitoring and quantification of BrCN generation was enabled through the implementation of in\u2010line FTIR technology. With the Br<jats:sub>2<\/jats:sub> and BrCN generators connected in series, 0.2\u2005mmol BrCN per minute was produced, which corresponds to a 0.8\u2009<jats:sc>m<\/jats:sc> solution of BrCN in dichloromethane. The modular Br<jats:sub>2<\/jats:sub>\/BrCN generator was employed for the synthesis of a diverse set of biologically relevant five\u2010 and six\u2010membered cyclic amidines and guanidines. The set\u2010up can either be operated in a fully integrated continuous format or, where reactive crystallization is beneficial, in semi\u2010batch mode.<\/jats:p>","DOI":"10.1002\/anie.201708533","type":"journal-article","created":{"date-parts":[[2017,9,6]],"date-time":"2017-09-06T16:07:14Z","timestamp":1504714034000},"page":"13786-13789","source":"Crossref","is-referenced-by-count":52,"title":["Integration of Bromine and Cyanogen Bromide Generators for the Continuous\u2010Flow Synthesis of Cyclic Guanidines"],"prefix":"10.1002","volume":"56","author":[{"given":"Gabriel","family":"Glotz","sequence":"first","affiliation":[{"name":"Center for Continuous Flow Synthesis and Processing (CC FLOW) Research Center Pharmaceutical Engineering GmbH (RCPE)  Inffeldgasse 13 8010 Graz Austria"},{"name":"Institute of Chemistry, NAWI Graz University of Graz  Heinrichstrasse 28 8010 Graz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren\u00e9","family":"Lebl","sequence":"additional","affiliation":[{"name":"Center for Continuous Flow Synthesis and Processing (CC FLOW) Research Center Pharmaceutical Engineering GmbH (RCPE)  Inffeldgasse 13 8010 Graz Austria"},{"name":"Institute of Chemistry, NAWI Graz University of Graz  Heinrichstrasse 28 8010 Graz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1649-0465","authenticated-orcid":false,"given":"Doris","family":"Dallinger","sequence":"additional","affiliation":[{"name":"Institute of Chemistry, NAWI Graz University of Graz  Heinrichstrasse 28 8010 Graz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2983-6007","authenticated-orcid":false,"given":"C. 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