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The development of a unique class of NIR dyes via modifying the rhodol scaffold with fused tetrahydroquinoxaline rings is described. These new dyes showed large Stokes shifts (&gt;110\u2005nm). Among them, WR3, WR4, WR5, and WR6 displayed high fluorescence quantum yields and excellent photostability in aqueous solutions. Moreover, their fluorescence properties were tunable by easy modifications on the phenolic hydroxy group. Based on WR6, two NIR fluorescent turn\u2010on probes, WSP\u2010NIR and SeSP\u2010NIR, were devised for the detection of H\n                    <jats:sub>2<\/jats:sub>\n                    S. The probe SeSP\u2010NIR was applied in visualizing intracellular H\n                    <jats:sub>2<\/jats:sub>\n                    S. These dyes are expected to be useful fluorophore scaffolds in the development of new NIR probes for bioimaging.\n                  <\/jats:p>","DOI":"10.1002\/anie.201710688","type":"journal-article","created":{"date-parts":[[2017,11,13]],"date-time":"2017-11-13T21:58:42Z","timestamp":1510610322000},"page":"16611-16615","source":"Crossref","is-referenced-by-count":201,"title":["A General Strategy for Development of Near\u2010Infrared Fluorescent Probes for Bioimaging"],"prefix":"10.1002","volume":"56","author":[{"given":"Wei","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Chemistry Washington State University  Pullman WA 99164 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Chemistry Washington State University  Pullman WA 99164 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob 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