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To date, only limited strategies involving direct asymmetric trifluoromethylation have been reported. Herein, we describe a new strategy for direct asymmetric trifluoromethylation through the copper\u2010catalyzed stereospecific trifluoromethylation of optically active secondary propargyl sulfonates. The reaction enables propargylic trifluoromethylation with high regioselectivity and stereoselectivity. The reaction could also be extended to stereospecific propargylic difluoroalkylation. Transformations of the resulting enantiomerically enriched fluoroalkylated alkynes led to a variety of chiral fluoroalkylated compounds, thus providing a useful protocol for applications in the synthesis of fluorinated complexes.<\/jats:p>","DOI":"10.1002\/anie.201711463","type":"journal-article","created":{"date-parts":[[2018,1,23]],"date-time":"2018-01-23T07:12:49Z","timestamp":1516691569000},"page":"3187-3191","source":"Crossref","is-referenced-by-count":75,"title":["Copper\u2010Catalyzed Highly Stereoselective Trifluoromethylation and Difluoroalkylation of Secondary Propargyl Sulfonates"],"prefix":"10.1002","volume":"57","author":[{"given":"Xing","family":"Gao","sequence":"first","affiliation":[{"name":"Key Laboratory of Organofluorine Chemistry, Center for Excellence in Molecular Synthesis Shanghai Institute of Organic Chemistry University of Chinese Academy of Sciences Chinese Academy of Sciences  345 Lingling Lu Shanghai 200032 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Lan","family":"Xiao","sequence":"additional","affiliation":[{"name":"Key Laboratory of Organofluorine Chemistry, Center for Excellence in Molecular Synthesis Shanghai Institute of Organic Chemistry University of Chinese Academy of Sciences Chinese Academy of Sciences  345 Lingling Lu Shanghai 200032 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolong","family":"Wan","sequence":"additional","affiliation":[{"name":"Key Laboratory of Organofluorine Chemistry, Center for Excellence in Molecular Synthesis Shanghai Institute of Organic Chemistry University of Chinese Academy of Sciences Chinese Academy of Sciences  345 Lingling Lu Shanghai 200032 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4406-6533","authenticated-orcid":false,"given":"Xingang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of 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