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The copolymers feature a poly(glutamic acid) (PGA) backbone bearing hydroxybenzaldehyde (HBA) functions and cyclic poly(2\u2010methyl\u20102\u2010oxazoline) (PMOXA) side chains. PGA\u2010PMOXA\u2010HBA species chemisorb on the degraded tissue via Schiff bases and expose the biopassive and lubricious PMOXA cyclic grafts at the interface. The smaller hydrodynamic radius by cyclic PMOXA side chains coupled to the intrinsic absence of chain ends generate denser and more lubricious films on cartilage when compared to those produced by copolymers bearing linear PMOXA. Topology effects demonstrate how the introduction of cyclic polymers within tissue\u2010reactive copolymers substantially improve their tribological and biopassive properties, suggesting a plethora of possible applications for cyclic macromolecules in biomaterials formulations.<\/jats:p>","DOI":"10.1002\/anie.201712534","type":"journal-article","created":{"date-parts":[[2017,12,28]],"date-time":"2017-12-28T15:27:09Z","timestamp":1514474829000},"page":"1621-1626","source":"Crossref","is-referenced-by-count":107,"title":["Cyclic Polymer Grafts That Lubricate and Protect Damaged Cartilage"],"prefix":"10.1002","volume":"57","author":[{"given":"Giulia","family":"Morgese","sequence":"first","affiliation":[{"name":"Polymer Surfaces Group Laboratory for Surface Science and Technology Department of Materials ETH Z\u00fcrich  Z\u00fcrich Switzerland"},{"name":"Tissue Engineering and Biofabrication Group Department of Health Science and Technology ETH Z\u00fcrich  Z\u00fcrich 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