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Previous studies have indicated that PrP interacts with Alzheimer\u2032s disease amyloid\u2010\u03b2 peptide (A\u03b2), but it remains elusive how this interaction impacts on the misfolding of PrP. This study presents the first in\u2005vitro evidence that A\u03b2 induces PrP\u2010amyloid formation at submicromolar concentrations. Interestingly, systematic mutagenesis of PrP revealed that A\u03b2 requires no specific amino acid sequences in PrP, and induces the misfolding of other unrelated proteins (insulin and lysozyme) into amyloid fibrils in a manner analogous to PrP. This unanticipated nonspecific amyloidogenic effect of A\u03b2 indicates that this peptide might be involved in widespread protein aggregation, regardless of the amino acid sequences of target proteins, and exacerbate the pathology of many neurodegenerative diseases.<\/jats:p>","DOI":"10.1002\/anie.201800197","type":"journal-article","created":{"date-parts":[[2018,4,12]],"date-time":"2018-04-12T10:23:14Z","timestamp":1523528594000},"page":"6086-6089","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Amyloid\u2010\u03b2 Peptide Induces Prion Protein Amyloid Formation: Evidence for Its Widespread Amyloidogenic Effect"],"prefix":"10.1002","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3698-5975","authenticated-orcid":false,"given":"Ryo","family":"Honda","sequence":"first","affiliation":[{"name":"The United Graduate School of Drug Discovery and Medical Information Sciences Gifu University  1-1 Yanagido Gifu 501-1194 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,4,23]]},"reference":[{"key":"e_1_2_2_1_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a006833"},{"key":"e_1_2_2_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05294"},{"key":"e_1_2_2_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4018"},{"key":"e_1_2_2_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/359325a0"},{"key":"e_1_2_2_5_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.11.6448"},{"key":"e_1_2_2_6_1","unstructured":"\u00a0"},{"key":"e_1_2_2_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature07761"},{"key":"e_1_2_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2017.11.020"},{"key":"e_1_2_2_9_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.145516"},{"key":"e_1_2_2_10_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.423954"},{"key":"e_1_2_2_11_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0911829107"},{"key":"e_1_2_2_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms1341"},{"key":"e_1_2_2_13_1","unstructured":"\u00a0"},{"key":"e_1_2_2_14_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.12-222588"},{"key":"e_1_2_2_15_2","author":"Bove-Fenderson E.","year":"2017","journal-title":"J. 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