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However, reliable strategies for high\u2010level drug encapsulation within ferritin cavities and prompt cellular drug release are still lacking. Ferritin nanocages were developed with partially opened hydrophobic channels, which provide stable routes for spontaneous and highly accumulated loading of Fe<jats:sup>II<\/jats:sup>\u2010conjugated drugs as well as pH\u2010responsive rapid drug release at endoplasmic pH. Multiple cancer\u2010related compounds, such as doxorubicin, curcumin, and quercetin, were actively and heavily loaded onto the prepared nicked ferritin. Drugs on these minimally modified ferritins were effectively delivered inside cancer cells with high toxicity.<\/jats:p>","DOI":"10.1002\/anie.201800516","type":"journal-article","created":{"date-parts":[[2018,1,23]],"date-time":"2018-01-23T07:08:51Z","timestamp":1516691331000},"page":"2909-2913","source":"Crossref","is-referenced-by-count":80,"title":["Four\u2010fold Channel\u2010Nicked Human Ferritin Nanocages for Active Drug Loading and pH\u2010Responsive Drug Release"],"prefix":"10.1002","volume":"57","author":[{"given":"Byungjun","family":"Ahn","sequence":"first","affiliation":[{"name":"Department of Chemistry Korea Advanced Institute of Science and Technology  Daejeon 305-701 Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seong\u2010Gyu","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences Korea Advanced Institute of Science and Technology  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