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A ruthenium(II)\u2010complex\u2010based luminescence probe, <jats:bold>Ru\u2010MDB<\/jats:bold> (MDB: 4\u2019\u2010methyl\u2010[2,2\u2019\u2010bipyridine]\u20104\u2010yl)methyl 2\u2010((2,4\u2010dinitrophenyl)thio)benzoate), was developed by introducing a new H<jats:sub>2<\/jats:sub>S responsive masking moiety to a red\u2010emitting Ru<jats:sup>II<\/jats:sup> luminophore. Cleavage of this masking group by a H<jats:sub>2<\/jats:sub>S\u2010triggered reaction leads to a luminescence \u201coff\u2013on\u201d response. The long\u2010lived emissions of <jats:bold>Ru\u2010MDB<\/jats:bold> and its reaction product with H<jats:sub>2<\/jats:sub>S allowed quantitative detection of H<jats:sub>2<\/jats:sub>S in autofluorescence\u2010rich human sera and adult zebrafish organs using the time\u2010gated luminescence mode. <jats:bold>Ru\u2010MDB<\/jats:bold> exhibits red emission, a large Stokes shift, high specificity and sensitivity for H<jats:sub>2<\/jats:sub>S detection, and low cytotoxicity, which enables imaging and flow cytometry analysis of lysosomal H<jats:sub>2<\/jats:sub>S generation in live inflamed cells under drug stimulation. Monitoring of H<jats:sub>2<\/jats:sub>S in live <jats:italic>Daphnia magna<\/jats:italic>, zebrafish embryos, adult zebrafish, and mice, was conducted by in\u2005vivo imaging using <jats:bold>Ru\u2010MDB<\/jats:bold> as a probe.<\/jats:p>","DOI":"10.1002\/anie.201800540","type":"journal-article","created":{"date-parts":[[2018,2,2]],"date-time":"2018-02-02T16:42:41Z","timestamp":1517589761000},"page":"3999-4004","source":"Crossref","is-referenced-by-count":127,"title":["Quantitative Monitoring and Visualization of Hydrogen Sulfide In\u2005Vivo Using a Luminescent Probe Based on a Ruthenium(II) Complex"],"prefix":"10.1002","volume":"57","author":[{"given":"Zhongbo","family":"Du","sequence":"first","affiliation":[{"name":"State Key Laboratory of Fine Chemicals School of Chemistry Dalian University of Technology  Dalian 116024 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Song","sequence":"additional","affiliation":[{"name":"State Key Laboratory of 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