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Hindering the study of persulfides is a lack of persulfide\u2010donor compounds with selective triggers that release discrete persulfide species. Reported here is the synthesis and characterization of a ROS\u2010responsive (ROS=reactive oxygen species), self\u2010immolative persulfide donor. The donor, termed BDP\u2010NAC, showed selectivity towards H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    over other potential oxidative or nucleophilic triggers, resulting in the sustained release of the persulfide of\n                    <jats:italic>N<\/jats:italic>\n                    \u2010acetyl cysteine (NAC) over the course of 2\u2005h, as measured by LCMS. Exposure of H9C2 cardiomyocytes to H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    revealed that BDP\u2010NAC mitigated the effects of a highly oxidative environment in a dose\u2010dependent manner over relevant controls and to a greater degree than common H\n                    <jats:sub>2<\/jats:sub>\n                    S donors sodium sulfide (Na\n                    <jats:sub>2<\/jats:sub>\n                    S) and GYY4137. BDP\u2010NAC also rescued cells more effectively than a non\u2010persulfide\u2010releasing control compound in concert with common H\n                    <jats:sub>2<\/jats:sub>\n                    S donors and thiols.\n                  <\/jats:p>","DOI":"10.1002\/anie.201803087","type":"journal-article","created":{"date-parts":[[2018,4,26]],"date-time":"2018-04-26T05:39:31Z","timestamp":1524721171000},"page":"6324-6328","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":122,"title":["A Persulfide Donor Responsive to Reactive Oxygen Species: Insights into Reactivity and Therapeutic Potential"],"prefix":"10.1002","volume":"57","author":[{"given":"Chadwick R.","family":"Powell","sequence":"first","affiliation":[{"name":"Department of Chemistry Virginia Tech Center for Drug Discovery Macromolecules Innovation Institute Virginia Tech  Blacksburg VA 24061 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kearsley M.","family":"Dillon","sequence":"additional","affiliation":[{"name":"Department of Chemistry Virginia Tech Center for Drug Discovery Macromolecules Innovation Institute Virginia Tech  Blacksburg VA 24061 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Chemistry Virginia Tech Center for Drug Discovery Macromolecules Innovation Institute Virginia Tech  Blacksburg VA 24061 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan J.","family":"Carrazzone","sequence":"additional","affiliation":[{"name":"Department of Chemistry Virginia Tech Center for Drug Discovery Macromolecules Innovation Institute Virginia Tech  Blacksburg VA 24061 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7984-5396","authenticated-orcid":false,"given":"John B.","family":"Matson","sequence":"additional","affiliation":[{"name":"Department of Chemistry Virginia Tech Center for Drug Discovery Macromolecules Innovation Institute Virginia Tech  Blacksburg VA 24061 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,4,26]]},"reference":[{"key":"e_1_2_2_1_1","unstructured":"\u00a0"},{"key":"e_1_2_2_2_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.02-0211hyp"},{"key":"e_1_2_2_3_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0908047106"},{"key":"e_1_2_2_4_2","first-page":"2","volume":"2","author":"Mustafa A. 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