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We report the first comprehensive study on Be complexes with monodentate carboxylic acids, esters, aldehydes, and alcohols. Through solution and solid\u2010state techniques we determined that the binding affinities of Be<jats:sup>2+<\/jats:sup> ions towards the functional groups are: carboxylate &gt; alcohol &gt; aldehyde &gt; ester. Crystal structures of all the compounds have been determined including the unprecedented dodeca\u2010nuclear macrocyclic ring structure of non\u2010basic beryllium benzoate, which is the first example of those beryllium carboxylates. These findings enable the evaluation of potential beryllium binding sites inside proteins and is required to understand the mechanism of metal\u2010triggered immune responses.<\/jats:p>","DOI":"10.1002\/anie.201803667","type":"journal-article","created":{"date-parts":[[2018,4,23]],"date-time":"2018-04-23T02:18:16Z","timestamp":1524449896000},"page":"9180-9184","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Beryllium Complexes with Bio\u2010Relevant Functional Groups: Coordination Geometries and Binding Affinities"],"prefix":"10.1002","volume":"57","author":[{"given":"Matthias","family":"M\u00fcller","sequence":"first","affiliation":[{"name":"Anorganische Chemie Nachwuchsgruppe Berylliumchemie Fachbereich Chemie Philipps-Universit\u00e4t Marburg  Hans-Meerwein-Strasse 4 35032 Marburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3242-6797","authenticated-orcid":false,"given":"Magnus R.","family":"Buchner","sequence":"additional","affiliation":[{"name":"Anorganische Chemie Nachwuchsgruppe Berylliumchemie Fachbereich Chemie Philipps-Universit\u00e4t Marburg  Hans-Meerwein-Strasse 4 35032 Marburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,5,16]]},"reference":[{"key":"e_1_2_2_1_1","unstructured":"\u00a0"},{"key":"e_1_2_2_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.341.6141.26"},{"key":"e_1_2_2_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature06939"},{"key":"e_1_2_2_4_1","unstructured":"\u00a0"},{"key":"e_1_2_2_5_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.11-184556"},{"key":"e_1_2_2_6_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1135299"},{"key":"e_1_2_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2012.06.002"},{"key":"e_1_2_2_8_1","unstructured":"\u00a0"},{"key":"e_1_2_2_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2306"},{"key":"e_1_2_2_10_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1300392110"},{"key":"e_1_2_2_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.04.048"},{"key":"e_1_2_2_12_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.8105535"},{"key":"e_1_2_2_13_1","unstructured":"\u00a0"},{"key":"e_1_2_2_14_2","first-page":"155","volume":"26","author":"Vauquelin L.-N.","year":"1798","journal-title":"Ann. 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