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Dichloromethane (DCM) is for the first time recognized as a novel reagent in the synthetic chemistry of tetrazines. Using this novel approach 11 3\u2010aryl\/alkyl 1,2,4,5\u2010tetrazines were prepared in excellent yields (up to 75\u2009%). The mechanism of this new reaction, including the role of DCM in the tetrazine ring formation, has been investigated by\n                    <jats:sup>13<\/jats:sup>\n                    C\u2005labeling of DCM, and is also presented and discussed as well as the photophysical and electrochemical properties.\n                  <\/jats:p>","DOI":"10.1002\/anie.201804878","type":"journal-article","created":{"date-parts":[[2018,7,17]],"date-time":"2018-07-17T05:40:33Z","timestamp":1531806033000},"page":"12057-12061","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":85,"title":["Metal\u2010Free Synthetic Approach to 3\u2010Monosubstituted Unsymmetrical 1,2,4,5\u2010Tetrazines Useful for Bioorthogonal Reactions"],"prefix":"10.1002","volume":"57","author":[{"given":"Yangyang","family":"Qu","sequence":"first","affiliation":[{"name":"PPSM- CNRS- ENS Paris-Saclay  61 Avenue Pr\u00e9sident Wilson 94235 Cachan 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