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Notably, this is the first successful use of ketimines in the ProPhenol Mannich process, and the reaction offers a new approach for the preparation of pharmaceutically relevant products possessing trifluoromethylated tetrasubstituted alkylamines. The reaction can be performed on large scale with reduced catalyst loading without impacting its efficiency. Moreover, the acetylene moiety can be further elaborated using various methods.<\/jats:p>","DOI":"10.1002\/anie.201806249","type":"journal-article","created":{"date-parts":[[2018,7,2]],"date-time":"2018-07-02T19:07:53Z","timestamp":1530558473000},"page":"11408-11412","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":89,"title":["Direct Catalytic Asymmetric Vinylogous Additions of \u03b1,\u03b2\u2010 and \u03b2,\u03b3\u2010Butenolides to Polyfluorinated Alkynyl Ketimines"],"prefix":"10.1002","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7369-9121","authenticated-orcid":false,"given":"Barry M.","family":"Trost","sequence":"first","affiliation":[{"name":"Department of Chemistry Stanford University  Stanford CA 94305-5080 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7569-5837","authenticated-orcid":false,"given":"Chao\u2010I. 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