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Hydrophobic forces drive the dienes into the cavitands in conformations that best fill the available space. Shorter dienes (C9 and C10) bind in compressed conformations that tumble rapidly in the cavitands. Longer dienes induce capsule formation between cavitands with self\u2010complementary hydrogen bonding sites, where the dienes exist in extended conformations. In cavitands unable to form capsules, longer dienes adopt folded structures. The wider open ends allow the synthesis of medium\u2010sized cycloalkenes by ring\u2010closing metathesis reactions with the Hoveyda\u2013Grubbs\u2010II catalyst. Yields of cycloheptene and cyclooctene were enhanced by the chaperones in water when compared with reactions of the free dienes in either aqueous media or chloroform, and even cyclononene could be prepared within the cavitand.\n                  <\/jats:p>","DOI":"10.1002\/anie.201808265","type":"journal-article","created":{"date-parts":[[2018,9,24]],"date-time":"2018-09-24T01:13:26Z","timestamp":1537751606000},"page":"15091-15095","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":52,"title":["Cavitands as Containers for \u03b1,\u03c9\u2010Dienes and Chaperones for Olefin Metathesis"],"prefix":"10.1002","volume":"57","author":[{"given":"Nai\u2010Wei","family":"Wu","sequence":"first","affiliation":[{"name":"Center for Supramolecular and Catalytic Chemistry and Department of Chemistry Shanghai University  99 Shang-Da Road Shanghai 200444 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioannis 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